2. GPCR/G Protein
  3. CaSR
  4. Etelcalcetide

Etelcalcetide  (Synonyms: Velcalcetide; AMG 416; KAI-4169)

目录号: HY-P1955
产品使用指南

摩尔计算器

Etelcalcetide (AMG 416; KAI-4169) 是一种合成的 钙敏感受体 (CaSR) 的活化剂。Etelcalcetide 能有效降低接受血液透析的继发性甲状旁腺功能亢进患者的甲状旁腺激素 (PTH) 浓度，有望用于继发性甲状旁腺功能亢进症和慢性肾病领域的研究。

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Etelcalcetide Chemical Structure

Etelcalcetide Chemical Structure

CAS No. : 1262780-97-1

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Etelcalcetide 的其他形式现货产品:

Customer Review

Other Forms of Etelcalcetide:

Etelcalcetide 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Etelcalcetide (AMG 416; KAI-4169) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease[1][2].
体外研究
(In Vitro)

Etelcalcetide hydrochloride (0-100 µmol/L, 2 h) 剂量依赖性降低人甲状旁腺细胞中的甲状旁腺激素 (PTH) 水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Etelcalcetide 相关抗体:
体内研究
(In Vivo)

Etelcalcetide hydrochloride (2.5 µg/h 和 20 µg/h, 灌注, 3 天) 显著降低血浆 PTH 浓度，并且在较高的流速下降低 Cyp24a1 在肾脏的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL7/6J male mice
Dosage: 2.5 µg/h and 20 µg/h
Administration: infusion, 3 days
Result: Significantly reduced plasma PTH concentrations and unaltered Cldn14 expression with 2.5 µg/h, but decreased the renal expression of Cyp24a1 with 20 µg/h[1]
Clinical Trial
分子量

1048.25

Formula

C38H73N21O10S2
CAS 号
Sequence Shortening

C1' . Ac-{d-Cys1}-{d-Ala}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Ala}-{d-Arg}-NH2 (Disulfide bridge: Cys1'-Cys1)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Etelcalcetide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etelcalcetide1262780-97-1Velcalcetide AMG 416 KAI-4169AMG416AMG 416AMG-416KAI4169KAI 4169KAI-4169CaSRCalcium-sensing receptorsecondary hyperparathyroidismchronic kidney diseasecalcimimeticPTHInhibitorinhibitorinhibit

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