Ethoxylated hydrogenated castor oil  (Synonyms: PEG-40 hydrogenated castor oil; Macrogolglycerol hydroxystearate; Castor oil, hydrogenated, polyethoxylated)

Ethoxylated hydrogenated castor oil (PEG-40 hydrogenated castor oil) is a combination of synthetic polyethylene glycol (PEG) with natural castor oil. Ethoxylated hydrogenated castor oil can be used to emulsify and solubilize oil-in-water (o/w) emulsions. Ethoxylated hydrogenated castor oil can be used as a cosolvent in vivo^[1].

将 20% PEG-40 氢化蓖麻油 (10 ul) 应用于小鼠的左耳，右耳作为对照。连续 6 天观察小鼠皮疹的发展情况，未观察到小鼠有刺激迹象^[1]。
PEG-40 氢化蓖麻油 (尾静脉注射；300、900 和 2700 mg/kg；4 周) 用于短期毒性。在 300 和 900 mg/kg 的剂量下，PEG-40 氢化蓖麻油没有表现出全身毒性。然而，在2700 mg/kg剂量下，雄性体重明显下降，雌性体重轻度下降^[1]。
空白纳米乳的毒性研究，PEG-40氢化蓖麻油作为表面活性剂用于负载多种口服活性化合物^[2]。
近20%的PEG-40氢化蓖麻油被用于将单油酸甘油酯 (GMO) 作为油乳化到水相中。在韦氏小鼠中，给小鼠口服5000 mg/kg空白纳米乳剂，每日一次，连续14天，该纳米乳剂不产生危害作用，对食物摄入无影响^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

61788-85-0

油状物

Colorless to light yellow

聚氧乙烯氢化蓖麻油

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. PEG-40 HYDROGENATED CASTOR OIL

  [2]. Heni Rachmawati, et al. The In Vitro-In Vivo Safety Confirmation of PEG-40 Hydrogenated Castor Oil as a Surfactant for Oral Nanoemulsion Formulation. Sci Pharm. 2017 Mar 31;85(2):18. doi: 10.3390/scipharm85020018.  [Content Brief]

  [3]. PEGylated Oils as Used in Cosmetics