2. Anti-infection
  3. Bacterial
  4. F-17

F-17 是一种潜在的 virulence factor 抑制剂。F-17 对生物膜、弹性蛋白酶、绿脓素和蜂群运动有非常显着的抑制作用。F-17 对 LasR 和 PqsR 也显示出良好的结合效果。F-17 无明显细胞毒性。

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F-17 Chemical Structure

F-17 Chemical Structure

CAS No. : 1572464-22-2

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F-17 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

F-17 is a potential inhibitor of virulence factor. F-17 shows very significant inhibitory effect on biofilm, elastase, pyocyanin, and swarming motility. F-17 also shows a good binding effect on LasR and PqsR. F-17 has no obvious cytotoxicity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DU-145 IC50
35.4 μM
Compound: Table 1, 4'=Br
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
[PMID: 27979593]
ECa-109 cell line IC50
40.3 μM
Compound: Table 1, 4'=Br
Antiproliferative activity against human ECA109 cells after 48 hrs by MTT assay
Antiproliferative activity against human ECA109 cells after 48 hrs by MTT assay
[PMID: 27979593]
HeLa IC50
56.8 μM
Compound: Table 1, 4'=Br
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 27979593]
MCF7 IC50
28.2 μM
Compound: Table 1, 4'=Br
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 27979593]
Clinical Trial
分子量

363.20

Formula

C17H15BrO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

F-17 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

F-171572464-22-2F17F 17Bacterialvirulence factorbiofilmelastasepyocyaninswarming motilityLasRPqsRcytotoxicityInhibitorinhibitorinhibit

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