2. Protein Tyrosine Kinase/RTK Apoptosis Autophagy
  3. FAK Apoptosis Autophagy
  4. FAK-IN-5

FAK-IN-5 (Compound 8l) 是一种 FAK signaling 抑制剂。FAK-IN-5 诱导细胞凋亡(apoptosis) 和自噬 (autophagy)。

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FAK-IN-5 Chemical Structure

FAK-IN-5 Chemical Structure

CAS No. : 2408317-70-2

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FAK-IN-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FAK-IN-5 (Compound 8l) is a FAK signaling inhibitor. FAK-IN-5 induces cell apoptosis and autophagy[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM GI50
7.9 μM
Compound: 8l
Antiproliferative activity against human CEM cells assessed as growth inhibition measured after 72 hrs by calcein AM dye-based fluorescence assay
Antiproliferative activity against human CEM cells assessed as growth inhibition measured after 72 hrs by calcein AM dye-based fluorescence assay
[PMID: 31931341]
G-361 GI50
6.3 μM
Compound: 8l
Antiproliferative activity against human G361 cells assessed as growth inhibition measured after 72 hrs by calcein AM dye-based fluorescence assay
Antiproliferative activity against human G361 cells assessed as growth inhibition measured after 72 hrs by calcein AM dye-based fluorescence assay
[PMID: 31931341]
HCT-116 GI50
5.3 μM
Compound: 8l
Antiproliferative activity against human HCT116 cells assessed as growth inhibition measured after 72 hrs by calcein AM dye-based fluorescence assay
Antiproliferative activity against human HCT116 cells assessed as growth inhibition measured after 72 hrs by calcein AM dye-based fluorescence assay
[PMID: 31931341]
K562 GI50
6.3 μM
Compound: 8l
Antiproliferative activity against human K562 cells assessed as growth inhibition measured after 72 hrs by calcein AM dye-based fluorescence assay
Antiproliferative activity against human K562 cells assessed as growth inhibition measured after 72 hrs by calcein AM dye-based fluorescence assay
[PMID: 31931341]
MCF7 GI50
5.5 μM
Compound: 8l
Antiproliferative activity against human MCF7 cells assessed as growth inhibition measured after 72 hrs by calcein AM dye-based fluorescence assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition measured after 72 hrs by calcein AM dye-based fluorescence assay
[PMID: 31931341]
体外研究
(In Vitro)

FAK-IN-5 (Compound 8l) (0-50 µM, 72 h) shows antiproliferative activity against cancer cells[1].
FAK-IN-5 (Compound 8l) causes cell detachment[1].
FAK-IN-5 (Compound 8l) (0-25 µM, 24 h) induces autophagy and apoptosis in HCT-116 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FAK-IN-5 相关抗体:

Cell Proliferation Assay[1]

Cell Line: K562, CEM, G361, MCF-7 and HCT-116
Concentration: 0-50 µM
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50 values of 6.3, 7.9, 6.3, 5.5 and 5.3 µM against K562, CEM, G361, MCF-7 and HCT-116 cells, respectively.

Western Blot Analysis[1]

Cell Line: HCT-116
Concentration: 1.25, 2.5, 5, 7, 10, 11, 17 and 25 µM
Incubation Time: 1, 3, 5, 7 and 24 h
Result: Caused the dephosphorylation of FAK, p130Cas and paxillin in a dose-dependent manner. The dephosphorylation of FAK at Y397 was observed at a much earlier time point. Detected the fragments of activated caspase-7 as well as the dose-dependent cleavage of poly (ADP-ribose) polymerase (PARP).
分子量

576.01

Formula

C29H29ClF3N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FAK-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAK-IN-52408317-70-2FAKApoptosisAutophagyPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseK562CEMG361MCF-7HCT-116anticancerInhibitorinhibitorinhibit

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