2. Protein Tyrosine Kinase/RTK
  3. FAK
  4. FAK inhibitor 6

化合物26f不仅优化了有效抑制酶（IC50= 28.2 nM），也表现出相对较少的细胞毒性（IC50= 3.32 μM），并以剂量依赖性方式诱导MDA-MB-231细胞凋亡，有效阻断G0/G1期MDA-MB-231细胞。

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FAK inhibitor 6 Chemical Structure

FAK inhibitor 6 Chemical Structure

CAS No. : 2410056-27-6

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FAK inhibitor 6 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Compound 26F not only optimized the effective inhibitory enzyme (ic50= 28.2 nm), but also showed relatively less cytotoxicity (ic50= 3.32 μ M) And induced MDA-MB-231 cell apoptosis in a dose-dependent manner, effectively blocking MDA-MB-231 cells in g0/g1 phase.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.27 μM
Compound: 26f
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 31923858]
HK-2 IC50
3.32 μM
Compound: 26f
Cytotoxicity against human HK2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Cytotoxicity against human HK2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 31923858]
MDA-MB-231 IC50
0.19 μM
Compound: 26f
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 31923858]
U-87MG ATCC IC50
0.16 μM
Compound: 26f
Antiproliferative activity against human U-87MG cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human U-87MG cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 31923858]
分子量

477.55

Formula

C25H24FN5O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FAK inhibitor 6 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAK inhibitor 62410056-27-6FAK inhibitor6FAK inhibitor-6FAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseInhibitorinhibitorinhibit

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