2. Apoptosis
  3. Ferroptosis
  4. Ferroptosis-IN-8

Ferroptosis-IN-8 (化合物 B4) 是一种铁死亡抑制剂，IC50 值为 40.49 nM。Ferroptosis-IN-8 通过其固有的抗氧化能力来抑制 RSL3 (HY-100218A) 或 FIN56 (HY-103087) 诱导的铁死亡，显著减轻肝肾损伤，有望用于预防铁死亡相关疾病。

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Ferroptosis-IN-8 Chemical Structure

Ferroptosis-IN-8 Chemical Structure

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Ferroptosis-IN-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ferroptosis-IN-8 is a potent ferroptosis inhibitor with an EC50 of 40.49 nM. Ferroptosis-IN-8 effectively reduces lipid ROS levels in cells. Ferroptosis-IN-8 act as an antioxidant by capturing lipid radicals, leading to a reduction in the accumulation of harmful lipid peroxides and, ultimately, inhibiting ferroptosis[1].

IC50 & Target

IC50: 40.49 nM (Ferroptosis)
体外研究
(In Vitro)

Ferroptosis-IN-8 (化合物 B4) (200 nM) 有效将 HKC, HK-2, Khos, SW480 和 HTR-8/SVneo 细胞从 RSL3 或 FIN56 诱导的脱铁蛋白中拯救出来[1]。
Ferroptosis-IN-8 (化合物 B4) (200 nM) 主要依赖其固有的抗氧化能力而非包括脂质氧化代谢在内的经典信号通路来对抗铁死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis-IN-8 相关抗体:

Cell Viability Assay[1]

Cell Line: HKC, HK-2, HT-1080, Khos, SW480, and HTR-8/SVneo cells treatment with RSL3 or FIN56
Concentration: 200 nM
Incubation Time: 24 h
Result: Effectively rescued HKC, HK-2, HT-1080, Khos, SW480, and HTR-8/SVneo cells from ferroptosis induced by RSL3 or FIN56.

Real Time qPCR[1]

Cell Line: HT-1080 cell
Concentration: 200 nM
Incubation Time:
Result: Didn't significantly affect the protein levels of key factors related to lipid metabolism (ACSL4, ALOX15, and COX2), glutathione metabolism pathways (GPX4, SLC7A11), and iron metabolism (DMT1, TFRC, and FTH1)
体内研究
(In Vivo)

Ferroptosis-IN-8 (化合物 B4) (10 mg/kg, 两次, 缺血开始前1 h, 腹腔注射) 减轻肾缺血再灌注损伤小鼠模型中的组织损伤[1]。
Ferroptosis-IN-8 (化合物 B4) (10 mg/kg, 腹腔注射) 通过抑制脱铁蛋白减轻对乙酰氨基酚诱导的小鼠急性肝损伤模型[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: acetaminophen-induced acute liver injury mice model[1].
Dosage: 10 mg/kg
Administration: intraperitoneal injection (i.p.)
Result: Attenuated the increased plasma ALT and AST levels induced by acetaminophen, effectively reduced the injury response induced by acetaminophen[1].
Animal Model: kidney ischemia−reperfusion injury mice model[1].
Dosage: 10 mg/kg, twice, 1 h before ischemia onset.
Administration: intraperitoneal injection (i.p.)
Result: Reduced the levels of creatinine and BUN and alleviated the increase in KIM-1 levels in the I/R model[1].
Animal Model:
Dosage:
Administration:
Result:
Animal Model:
Dosage:
Administration:
Result:
分子量

285.30

Formula

C15H15N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ferroptosis-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis-IN-8FerroptosisFerroptosis inhibitorsRSL3lipid ROS levelskidney (I/R) injuryacute liver injuryInhibitorinhibitorinhibit

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