2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
  4. FF-10502

FF-10502 是 Gemcitabine 的结构类似物，是一种嘧啶核苷抗代谢物。FF-10502 抑制 DNA 聚合酶 α 和 β (DNA polymerase α/β)。FF-10502 通过对休眠细胞的作用机制显示出有益的抗癌活性。

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FF-10502 Chemical Structure

FF-10502 Chemical Structure

CAS No. : 184302-49-6

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FF-10502 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells[1].

体外研究
(In Vitro)

FF-10502 (0.1 nM-10 μM; 72 hours) shows the growth inhibition of pancreatic cancer cell lines, with IC50s of 59.9 nM, 39.6 nM, 68.2 nM, and 331.4 nM for BxPC-3, SUIT-2, Capan-1, and MIA PaCa-2 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FF-10502 相关抗体:

Cell Viability Assay[1]

Cell Line: Human pancreatic cancer cell lines (BxPC-3, SUIT-2, Capan-1, and MIA PaCa-2)
Concentration: 0.1 nM to 10 μM
Incubation Time: 72 hours
Result: Inhibited the growth of pancreatic cancer cell lines.
体内研究
(In Vivo)

FF-10502 (120-480 mg/kg; i.v; once weekly; for 4 weeks) shows an antitumor effect in a mouse xenograft model with the subcutaneously implanted human pancreatic cancer cell line Capan-1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old female nude mice (BALB/c-nu/nu) injected with Capan-1 cells[1].
Dosage: 120 mg/kg, 240 mg/kg, 360 mg/kg, and 480 mg/kg
Administration: Tail vein injection; once weekly; for 4 weeks
Result: Suppressed tumor growth in a dose-dependent manner in mice.
分子量

261.27

Formula

C9H12FN3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FF-10502 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FF-10502184302-49-6FF10502FF 10502Nucleoside Antimetabolite/AnalogDNA/RNA SynthesisDNA synthesisDNA polymerase αDNA polymerase βpyrimidine nucleoside antimetaboliteDNA repairanticancerInhibitorinhibitorinhibit

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