2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR4-IN-11

FGFR4-IN-11 (Compound 30) 是一种有效的、选择性的、共价结合的 FGFR4 抑制剂，IC50 值为 2.1 nM。FGFR4-IN-11 显著抑制 FGF19/FGFR4 信号通路，具有抗癌活性。

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FGFR4-IN-11 Chemical Structure

FGFR4-IN-11 Chemical Structure

CAS No. : 2396664-85-8

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FGFR4-IN-11 相关抗体

Top Publications Citing Use of Products

查看 FGFR 亚型特异性产品:

查看所有亚型
FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC50 of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity[1].

IC50 & Target

FGFR4

2.1 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Huh-7 IC50
26 nM
Compound: 30
Inhibition of cell proliferation in human Huh-7 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay
Inhibition of cell proliferation in human Huh-7 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay
[PMID: 35549181]
MDA-MB-453 IC50
6.3 nM
Compound: 30
Inhibition of cell proliferation in human MDA-MB-453 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay
Inhibition of cell proliferation in human MDA-MB-453 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay
[PMID: 35549181]
分子量

527.57

Formula

C29H29N5O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FGFR4-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR4-IN-112396664-85-8FGFRFibroblast growth factor receptorhepatocellular carcinomaHCCHuH-7MDA-MB-453breast cancerantitumor activityInhibitorinhibitorinhibit

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目录号：
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