2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR4-IN-6

FGFR4-IN-6 (Compound 9ka) 是一种共价可逆的 FGFR4 抑制剂，IC50 值为 5.4 nM。FGFR4-IN-6 具有良好的口服药代动力学特性。 FGFR4-IN-6 在 Hep3B2.1-7 HCC 细胞系的异种移植小鼠模型中显著诱导肿瘤消退，且没有明显的毒性。

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FGFR4-IN-6 Chemical Structure

FGFR4-IN-6 Chemical Structure

CAS No. : 2760970-10-1

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FGFR4-IN-6 相关抗体

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FGFR4-IN-6 (Compound 9ka) is a covalently reversible FGFR4 inhibitor with an IC50 value of 5.4 nM. FGFR4-IN-6 also exhibits good oral pharmacokinetic properties. FGFR4-IN-6 induces significant tumor regressions in a xenograft mouse model of Hep3B2.1-7 HCC cell line without an obvious sign of toxicity[1]. FGFR4-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

分子量

567.64

Formula

C31H33N7O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FGFR4-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR4-IN-62760970-10-1FGFRFibroblast growth factor receptorcovalently reversibleFGFR4 inhibitorgood oral pharmacokinetic propertiestumor regressionsInhibitorinhibitorinhibit

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