2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. Flanvotumab

Flanvotumab  (Synonyms: 法兰妥单抗; IMC-20D7S)

目录号: HY-P99622 纯度: 97.83%
COA

摩尔计算器

Flanvotumab (IMC-20D7S) 是一种靶向酪氨酸酶相关蛋白 (TYRP1) 的人源单克隆抗体，TYRP1 特异性表达于黑色素细胞和黑色素瘤细胞。Flanvotumab 通过自然杀伤介导的、抗体依赖的细胞介导的细胞毒作用 (ADCC) 而行使功能。Flanvotumab 具有较强的抗肿瘤活性和良好的耐受性。

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CAS No. : 1188277-05-5

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规格 价格 是否有货 数量
1 mg ￥2000
In-stock
5 mg ￥5800
In-stock
10 mg   询价  
50 mg   询价  

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Flanvotumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flanvotumab (IMC-20D7S) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab has potent anti-tumor activity and good tolerance[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Human
体外研究
(In Vitro)

Flanvotumab 是基于 TA99 而研制的，TA99 是一种小鼠 IgG2a 抗 TYRP1 单抗，定位于皮下黑色素瘤异种移植，并在临床前模型中抑制同基因肿瘤生长[1]。
TA99 的抗肿瘤作用依赖于完整的抗体、Fc 受体的存在和自然杀伤 (NK) 细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Flanvotumab 相关抗体:
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

法兰妥单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human TYRP1 Protein (His Tag) can bind Flanvotumab. The EC50 for this effect is 1.674 ng/mL.
纯度 & 产品资料
参考文献

Flanvotumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flanvotumab1188277-05-5IMC-20D7S法兰妥单抗TyrosinaseInhibitorinhibitorinhibit

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