2. Apoptosis
  3. Apoptosis
  4. Flavagline FL3

Flavagline FL3 是一种对癌细胞具有强效和选择性细胞毒性的 flavagline 类化合物。Flavagline FL3 通过触发凋亡诱导因子 (AIF) 和 caspase-12 易位到细胞核来诱导 HL60 和 Hela 细胞凋亡 (apoptosis)。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Flavagline FL3 Chemical Structure

Flavagline FL3 Chemical Structure

CAS No. : 1186012-80-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Flavagline FL3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flavagline FL3 is a flavagline with potent and selective cytotoxicity in cancer cells.Flavagline FL3 induces apoptosis of HL60 and Hela cells by triggering the translocation of Apoptosis Inducing Factor (AIF) and caspase-12 to the nucleus[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
< 1 nM
Compound: 3
Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay
[PMID: 19655762]
HCT-116 IC50
5.8 nM
Compound: 2, FL3
Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay
Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay
[PMID: 23072299]
HCT-116 IC50
7.6 nM
Compound: 1a
Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay
[PMID: 21142180]
HCT-15 IC50
1 nM
Compound: 3
Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay
Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay
[PMID: 19655762]
HepG2 IC50
4 nM
Compound: 3
Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay
Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay
[PMID: 19655762]
HL-60 IC50
< 1 nM
Compound: 3
Cytotoxicity against human HL60 cells after 72 hrs by MTS assay
Cytotoxicity against human HL60 cells after 72 hrs by MTS assay
[PMID: 19655762]
HL-60 IC50
3.8 nM
Compound: 2, FL3
Cytotoxicity against human HL60 cells incubated for 72 hrs by MTS assay
Cytotoxicity against human HL60 cells incubated for 72 hrs by MTS assay
[PMID: 23072299]
HL-60 IC50
4.5 nM
Compound: 1a
Cytotoxicity against human HL60R cells after 72 hrs by MTS assay
Cytotoxicity against human HL60R cells after 72 hrs by MTS assay
[PMID: 21142180]
HL-60 IC50
5.5 nM
Compound: 1a
Cytotoxicity against human HL60 cells after 72 hrs by MTS assay
Cytotoxicity against human HL60 cells after 72 hrs by MTS assay
[PMID: 21142180]
KB IC50
< 1 nM
Compound: 3
Cytotoxicity against human KB cells after 72 hrs by MTS assay
Cytotoxicity against human KB cells after 72 hrs by MTS assay
[PMID: 19655762]
KB IC50
15 nM
Compound: 1a
Cytotoxicity against human KB cells after 72 hrs by MTS assay
Cytotoxicity against human KB cells after 72 hrs by MTS assay
[PMID: 21142180]
KB IC50
2.4 nM
Compound: 2, FL3
Cytotoxicity against human KB cells incubated for 72 hrs by MTS assay
Cytotoxicity against human KB cells incubated for 72 hrs by MTS assay
[PMID: 23072299]
MCF7 IC50
< 1 nM
Compound: 3
Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay
Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay
[PMID: 19655762]
MCF7 IC50
1 nM
Compound: 3
Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
[PMID: 19655762]
MDA-MB-231 IC50
3.8 nM
Compound: 1a
Cytotoxicity against human MDA231 cells after 72 hrs by MTS assay
Cytotoxicity against human MDA231 cells after 72 hrs by MTS assay
[PMID: 21142180]
MDA-MB-435 IC50
8.7 nM
Compound: 1a
Cytotoxicity against human MDA435 cells after 72 hrs by MTS assay
Cytotoxicity against human MDA435 cells after 72 hrs by MTS assay
[PMID: 21142180]
PC-3 IC50
17 nM
Compound: 1a
Cytotoxicity against human PC3 cells after 72 hrs by MTS assay
Cytotoxicity against human PC3 cells after 72 hrs by MTS assay
[PMID: 21142180]
SK-OV-3 IC50
8.5 nM
Compound: 1a
Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay
Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay
[PMID: 21142180]
分子量

483.35

Formula

C25H23BrO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Flavagline FL3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flavagline FL31186012-80-5Flavagline FL 3Flavagline FL-3ApoptosiscytotoxicityapoptosisAIFcaspase-12Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Flavagline FL3
目录号：
HY-123554
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z