2. Immunology/Inflammation
  3. CD3
  4. Flotetuzumab

Flotetuzumab  (Synonyms: 伏妥珠单抗; MGD006; S80880)

目录号: HY-P99623 纯度: 98.71%
COA

摩尔计算器

Flotetuzumab (MGD006; S80880) 是一种双特异性 CD123/CD3 双亲和再靶向 (DART) 抗体。Flotetuzumab 通过同时结合靶细胞的 CD123 和效应 T 细胞的 CD3，而重新激活 T 细胞，导致 T 细胞介导的靶细胞的细胞毒性。Flotetuzumab 对小鼠中急性髓系白血病 (AML) 患者来源异种移植物 (PDX) 模型具有抑制效力。

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CAS No. : 1664355-28-5

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1 mg ￥7500
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Flotetuzumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flotetuzumab (MGD006; S80880) is an investigational CD123/CD3 bispecific dual-affinity retargeting antibody (DART) molecule. Flotetuzumab reactivates T cells by simultaneously binding to CD123 in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML)[1][2].

同型

V-lambda-VH _ V-kappa-VH'
种属

Humanized
IC50 & Target

CD123, CD3[1]
体外研究
(In Vitro)

Flotetuzumab (0.01 ng/mL, 0.1 ng/mL; 144 h) increases IFN-γ, IL-10, and IL-6 secretion in primary PBMCs[1].
Flotetuzumab (10-6-102 ng/mL; 24 h) shows cytotoxicity against the Kasumi-3 AML cell line using human PBMCs or cynomolgus[1].
Flotetuzumab (0.01 ng/mL, 0.1 ng/mL; 6 d) dose-dependently inhibits leukemic blasts growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Flotetuzumab 相关抗体:

Cell Viability Assay[1]

Cell Line: Primary PBMCs
Concentration: 0.01 ng/mL, 0.1 ng/mL
Incubation Time: 6 days
Result: Resulted in a dose-dependent depletion of leukemic blasts, accompanied by a concomitant expansion of autologous T cells, up-regulation of the proliferation marker Ki-67, and a proportionally greater expansion of CD8+ cells.
体内研究
(In Vivo)

Flotetuzumab (0.5-4 μg/kg; intraperitoneal implantation; continuous infusion for 6 d) shows antitumor activity in human peripheral blood mononuclear cells (PBMCs)-reconstituted tumor-bearing mice[1].
Flotetuzumab (0.5 mg/kg; once every 5 d; for 30 d) improves mouse survival and induces T-cell proliferation in mouse NTPL-146 patient-derived xenograft (PDX) model of acute myeloid leukemia (AML)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PBMCs-reconstituted tumor model: NSG/β2m-/- mice intradermally implanted with the KG-1a (AML-M0) cells on day 0 and intraperitoneally injected with human PBMCs on day 1[1]
Dosage: 0.5 μg/kg, 1 μg/kg, and 4 μg/kg;
Administration: Peritoneally implantation with mini-osmotic pumps; continuous infusion from days 16 to 22;
Result: Inhibited tumor volume significantly.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

伏妥珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • V-Lambda-VH_V-Kappa-VH'
Biological Activity
  • Immobilized Flotetuzumab can bind Human IL-3R alpha/CD123 Protein (hFc Tag). The EC50 for this effect is 3.75 ng/mL.
  • Immobilized Flotetuzumab can bind Human CD3 epsilon/CD3e Protein (ECD, hFc Tag). The EC50 for this effect is 1.33 ng/mL.
纯度 & 产品资料
参考文献

Flotetuzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flotetuzumab1664355-28-5MGD006 S80880伏妥珠单抗MGD 006MGD-006S80880S 80880S-80880CD3Cluster of differentiation 3Inhibitorinhibitorinhibit

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