2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK Apoptosis
  3. Topoisomerase FLT3 Apoptosis
  4. FLT3-IN-13

FLT3-IN-13 (compound 20) 是一种有效的抗白血病topoisomerase II 和 FLT3 双重抑制剂，IC50 分别为 2.26 μM 和 2.26 μM。FLT3-IN-13 将细胞周期阻滞在 G2/M 期，并诱导细胞凋亡 (apoptosis)。FLT3-IN-13具有抗细胞毒性活性，尤其是对白血病。

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FLT3-IN-13 Chemical Structure

FLT3-IN-13 Chemical Structure

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FLT3-IN-13 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FLT3-IN-13 (compound 20) is a potent and effective antileukemic topoisomerase II and FLT3 dual inhibitor with IC50 values of 2.26 μM and 2.26 μM, respectively. FLT3-IN-13 arrests cell cycle at G2/M phase and induce apoptosis. FLT3-IN-13 has anticytotoxic activity, particularly against leukemia[1].

IC50 & Target

IC50: 2.26 μM (TOPO II), 2.26 μM (FLT3)[1]
体外研究
(In Vitro)

FLT3-IN-13 (compound 20) has strong antiproliferative activity against HL-60 with an IC50 of 0.48 ± 0.08 μM[1].
FLT3-IN-13 arrests HL-60 cell cycle at G2/M phase (G1%: 24.76±1.00, S%: 21.26±1.72, G2%: 32.78±2.21, total apoptosis%: 21.36±2.73)[1].
FLT3-IN-13 induces apoptosis of HL-60 with early-apoptosis of 6.13±1.20% and late-apoptosis of 13.06±0.40%[1].
FLT3-IN-13 significantly upregulates P53, TNFα and caspase 3/7 proteins in the HL-60 cell line, and increases the Bax/Bcl-2 ratio[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FLT3-IN-13 相关抗体:
分子量

342.35

Formula

C20H14N4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FLT3-IN-13 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLT3-IN-13TopoisomeraseFLT3ApoptosisCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3LeukemiaantileukemicanticytotoxicHL-60Inhibitorinhibitorinhibit

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目录号：
HY-143278
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