2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. FLT3/ITD-IN-2

FLT3/ITD-IN-2 (Compound 17) 是一种有效的 FLT3-ITD 抑制剂，对 FLT3D835Y、FLT3 和 FLT3-ITD 的 IC50 值分别为 0.3、0.4 和 1.0 nM。FLT3/ITD-IN-2 有效抑制 FLT3 的磷酸化，对急性髓系白血病细胞具有良好的抗增殖活性。

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FLT3/ITD-IN-2 Chemical Structure

FLT3/ITD-IN-2 Chemical Structure

CAS No. : 2489446-59-3

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FLT3/ITD-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FLT3/ITD-IN-2 (Compound 17) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 1.0 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-2 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].

IC50 & Target

IC50: 0.3 nM (FLT3D835Y), 0.4 nM (FLT3), 1.0 nM (FLT3-ITD)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MOLM-13 IC50
1 nM
Compound: 17
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34583130]
MV4-11 IC50
1.3 nM
Compound: 17
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34583130]
分子量

489.49

Formula

C23H26F3N7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FLT3/ITD-IN-2 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLT3/ITD-IN-22489446-59-3FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3acute myeloid leukemiaAMLMV-4–11MOLM-13Inhibitorinhibitorinhibit

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