1. Antibody-drug Conjugate/ADC Related PROTAC
  2. ADC Linker PROTAC Linkers
  3. Fmoc-Hyp(Bom)-OH

Fmoc-Hyp(Bom)-OH 是可降解 (cleavable) 的 ADC linker,用于合成抗体偶联活性分子 (ADCs)。Fmoc-Hyp(Bom)-OH 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker,可用于合成 PROTAC

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Fmoc-Hyp(Bom)-OH Chemical Structure

Fmoc-Hyp(Bom)-OH Chemical Structure

CAS No. : 187223-15-0

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10 g ¥1200
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fmoc-Hyp(Bom)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Hyp(Bom)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<

IC50 & Target

Cleavable Linker

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

539.58

Formula

C28H33N3O8

CAS 号
性状

固体

颜色

White to pink

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Fmoc-Hyp(Bom)-OH
目录号:
HY-79125
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