2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. FQ

FQ 是一种酪氨酸酶 (tyrosinase) 抑制剂，能有效抑制蘑菇酪氨酸酶二酚酶活性 (IC50=120 μM)。FQ 可用于色素沉着的研究。

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FQ Chemical Structure

FQ Chemical Structure

CAS No. : 190838-76-7

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规格 是否有货
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FQ 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FQ is a tyrosinase inhibitor that effectively inhibits the diphenolase activity of mushroom tyrosinase (IC50=120 μM). FQ can be used in the study of pigmentation[1].

IC50 & Target

IC50：120 μM (Tyrosinase Diphenolase) [1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
1A9 ED50
> 20 μg/mL
Compound: 10
In vitro effective concentration required to reduce the number of human ovarian cancer (1A9) after 3-day incubation
In vitro effective concentration required to reduce the number of human ovarian cancer (1A9) after 3-day incubation
[PMID: 11354375]
A549 ED50
7.5 μg/mL
Compound: 10
In vitro effective concentration required to reduce the number of human lung carcinoma (A-549) after 3-day incubation
In vitro effective concentration required to reduce the number of human lung carcinoma (A-549) after 3-day incubation
[PMID: 11354375]
COLO 205 IC50
10 μM
Compound: 9b
Antiproliferative activity against human COLO205 cells by MTT assay
Antiproliferative activity against human COLO205 cells by MTT assay
[PMID: 22749421]
K562 IC50
17 μM
Compound: 9b
Antiproliferative activity against human K562 cells by MTT assay
Antiproliferative activity against human K562 cells by MTT assay
[PMID: 22749421]
KB ED50
> 20 μg/mL
Compound: 10
In vitro effective concentration required to reduce the number of Human epidermoid carcinoma cells (KB) of nasopharynx after 3-day incubation
In vitro effective concentration required to reduce the number of Human epidermoid carcinoma cells (KB) of nasopharynx after 3-day incubation
[PMID: 11354375]
KB ED50
6.5 μg/mL
Compound: 10
In vitro effective concentration required to reduce the number of P-glycoprotein-expressing human epidermoid carcinoma cells (KB-VIN) of nasopharynx after 3-day incubation
In vitro effective concentration required to reduce the number of P-glycoprotein-expressing human epidermoid carcinoma cells (KB-VIN) of nasopharynx after 3-day incubation
[PMID: 11354375]
MCF7 ED50
> 20 μg/mL
Compound: 10
In vitro effective concentration required to reduce the number of human breast cancer (MCF-7) after 3-day incubation
In vitro effective concentration required to reduce the number of human breast cancer (MCF-7) after 3-day incubation
[PMID: 11354375]
MDA-MB-231 IC50
20 μM
Compound: 9b
Antiproliferative activity against human MDA-MB-231 cells by MTT assay
Antiproliferative activity against human MDA-MB-231 cells by MTT assay
[PMID: 22749421]
Sf21 IC50
1102 nM
Compound: 13f
Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrate addition measured after 30 mins
Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrate addition measured after 30 mins
[PMID: 27163581]
SK-MEL-2 ED50
> 20 μg/mL
Compound: 10
In vitro effective concentration required to reduce the number of human melanoma cancer (SKMEL-2) after 3-day incubation
In vitro effective concentration required to reduce the number of human melanoma cancer (SKMEL-2) after 3-day incubation
[PMID: 11354375]
分子量

240.23

Formula

C14H9FN2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FQ 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FQ190838-76-7TyrosinaseTyrosine kinaseinhibitorpigmentationInhibitorinhibit

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