1. Stem Cell/Wnt TGF-beta/Smad
  2. TGF-beta/Smad
  3. Fresolimumab

Fresolimumab  (Synonyms: 非苏木单抗; GC1008)

目录号: HY-P99020 纯度: 99.51%
COA 技术支持

Fresolimumab (GC1008) 是一种人源化抗 TGF-β 的单克隆抗体,可以中和所有哺乳动物 TGF-β 的活性亚型。Fresolimumab 对 TGF-β2 的结合亲和力为 1.8 nM。用 89Zr 放射标记的 Fresolimumab 可用于 PET 分析 TGF-β 的表达、抗体肿瘤摄取和器官分布。Fresolimumab 可用于癌症、脆骨病、纤维化和肾脏疾病等的研究。

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CAS No. : 948564-73-6

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规格 价格 是否有货 数量
1 mg ¥5000
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5 mg ¥10500
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10 mg ¥14160
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25 mg ¥21000
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50 mg ¥28320
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100 mg ¥38280
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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fresolimumab (GC1008) is a human monoclonal antibody against TGF-β that neutralizes all mammalian active subtypes of TGF-β. The binding affinity of Fresolimumab to TGF-β2 is 1.8 nM. Fresolimumab radiolabeled with 89Zr can be used for PET analysis of TGF-β expression, antibody uptake and organ distribution. Fresolimumab can be used in the study of cancer, osteogenesis imperfecta, fibrosis and kidney disease[1][2][3].

同型

Human IgG4 kappa

推荐同型对照抗体
种属

Human

Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

非苏木单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized TGF beta 1/TGFB1 Protein, Human can bind Fresolimumab. The EC50 for this effect is 67.28 ng/mL.
纯度 & 产品资料

纯度: 99.51%

参考文献
  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Fresolimumab
目录号:
HY-P99020
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