2. Others
  3. Others
  4. FXIa-IN-10

FXIa-IN-10 (Compound 3f) 是一种有效的激活因子 XI (FXIa) 抑制剂，Ki 值为 0.17 nM。FXIa-IN-10 具有良好的口服生物利用度。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

FXIa-IN-10 Chemical Structure

FXIa-IN-10 Chemical Structure

CAS No. : 2816108-08-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of FXIa-IN-10:

FXIa-IN-10 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FXIa-IN-10 (Compound 3f) is a potent activated factor XI (FXIa) inhibitor with an Ki of 0.17 nM. FXIa-IN-10 has good oral bioavailability[1].

IC50 & Target

Ki: 0.17 nM (FXIa)[1]
体内研究
(In Vivo)

FXIa-IN-10 (Compound 3f) (1.7+2.0 and 8.5+10.0 (bolus + infusion) mg/kg; i.v.; twice) shows antithrombotic efficacy in a rabbit AV shunt thrombosis model[1].
FXIa-IN-10 (0-10 mg/kg; p.o.; once) demonstrates oral bioavailability in preclinical species (rat 36.4%, dog 80.5%, and monkey 43.0%)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male New Zealand White (NZW) rabbits, AV shunt thrombosis model[1]
Dosage: 1.7+2.0 and 8.5+10.0 (bolus + infusion) mg/kg
Administration: Intravenous injection, 20 min prior to and 40 min during the AV shunt
Result: Reduced thrombus weights in a dose-dependent manner.
Animal Model: Sprague-Dawley rats, Beagle dogs, Cynomolgus monkeys[1]
Dosage: 1, 2, 5 or 10 mg/kg
Administration: Intravenous or oral administration (Pharmacokinetic Analysis)
Result: Pharmacokinetic Profile of FXIa-IN-10 (Compound 3f) in Preclinical Speciesa[1]
animal species clearance (mL/min/kg) T1/2 (h) Vdss (L/kg) F% AUC (iv) (μM•h) AUC (po) (μM•h) Dose iv/po (mpk)
rat 10.7 ± 1.8 1.4 ± 0.0 0.8 ± 0.1 36.4 5.5 ± 1.0 10.0 ± 2.4 2/10
monkey 25.6 ± 4.0 1.0 ± 0.4 1.5 ± 0.4 43.0 1.1 ± 0.2 2.5 ± 0.3 1/5

aCompound was dosed as a free base, vehicle for iv: 20% HPbCD and po: 10% ethanol; 70% PEG-400; 20% water. Data were derived from three animals per study.
分子量

580.35

Formula

C23H18Cl2F3N9O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FXIa-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FXIa-IN-102816108-08-2Othersactivated factor XIFXIagood oral bioavailabilityantithrombotic efficacyInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
FXIa-IN-10
目录号：
HY-151196
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z