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  4. FXIIIa-IN-1

FXIIIa-IN-1 (Compound 16) 是一种强效的选择性 FXIIIa (Factor XIIIa) 抑制剂，IC50 值为 2.4 μM。FXIIIa-IN-1 通过与 Gln-供体蛋白底物 (二甲基酪蛋白) 竞争来抑制 FXIIIa。FXIIIa-IN-1 有望用于有效且安全的新型抗凝剂开发研究。

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FXIIIa-IN-1 Chemical Structure

FXIIIa-IN-1 Chemical Structure

CAS No. : 55909-92-7

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FXIIIa-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FXIIIa-IN-1 (Compound 16) is a potent and selective FXIIIa (Factor XIIIa) inhibitor with an IC50 value of 2.4 μM. FXIIIa-IN-1 inhibits FXIIIa by competing with the Gln-donor protein substrate (dimethylcasein). FXIIIa-IN-1 holds promise for the development of effective and safe novel anticoagulants[1].

IC50 & Target

IC50: 2.4 μM (Factor XIIIa)[1]; IC50: > 150 μM (Factor XIa)[1]; IC50: > 500 μM (Factor Xa)[1]; IC50: > 500 μM (Thrombin)[1];
体外研究
(In Vitro)

FXIIIa-IN-1 (10 μM，3 天) 在乳腺 (MCF-7 细胞)、肠道 (CaCo-2 细胞) 和肾脏 (HEK-293 细胞) 三种细胞系中无显著细胞毒性[1]。
FXIIIa-IN-1 (5-2000 μM，24 小时) 浓度依赖性地抑制基于 FXIIIa 的纤维蛋白 (ogen) 聚合和 γ-γ 二聚体的形成[1]。
FXIIIa-IN-1 (5 μL，5 min) 未影响其他凝血因子 (thrombin, factor Xa, factor XIa) ，对 FXIIIa 具有选择性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FXIIIa-IN-1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MCF-7 cells, HEK-293 cells, CaCo-2 cells
Concentration: 10 μM
Incubation Time: 3 days
Result: Did not significantly affect the proliferation of MCF-7 cells, HEK-293 cells, and CaCo-2 cells.
分子量

903.89

Formula

C26H25N5O19S6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FXIIIa-IN-1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FXIIIa-IN-155909-92-7OthersMCF-7 cellsHEK-293 cellsCaCo-2 cellsanticoagulant activityCardiovascular diseaseInhibitorinhibitorinhibit

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