GABAA receptor agent 7 

GABAA receptor agent 7 (compoud 5c) is a potent GABAA receptor positive modulator. GABAA receptor agent 7 shows anticonvulsant activity in vitro and in vivo with low neurotoxicity. GABAA receptor agent 7 has the potential for the research of epilepsy^[1].

GABAA receptor agent 7 (compoud 5c) shows anticonvulsant activity with an IC₅₀ of 0.452 µM in 4-AP induced hyper-excitability Model^[1].
GABAA receptor agent 7 (0.01-100 µM; 0-140 s) increases GABA-induced activation of GABAA1 receptor in a dose-dependent manner with EC₅₀ 3.08 µM^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GABAA receptor agent 7 shows anticonvulsant activity in mice with an ED₅₀ of 31.81 mg/kg and an TD₅₀ of 547.89 mg/kg^[1].
GABAA receptor agent 7 specifically attenuates PTZ-induced seizures but not MES-induced seizures in mice^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

336.78

C₁₈H₁₃ClN₄O

2376841-18-6

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Huang L, et al. Discovery of [1,2,4]-triazolo [1,5-a]pyrimidine-7(4H)-one derivatives as positive modulators of GABAA1 receptor with potent anticonvulsant activity and low toxicity. Eur J Med Chem. 2020 Jan 1;185:111824.  [Content Brief]