2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. GABAA receptor modular-3

GABAA receptor modular-3 (Compound S28) 是 (γ-氨基丁酸)A 受体 (GABAA 受体) 的调节剂，对 α1β2γ2 和 α4β3δ 亚型的 EC50 分别为 56 nM 和 10 nM。GABAA receptor modular-3 在大鼠体内表现出良好的药代动力学特征。GABAA receptor modular-3 在大鼠体内具有轻微毒性，翻滚反射丧失 (LORR) 阈值剂量为 23.3 μmol/kg，并表现出改善产后抑郁症的潜力。

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GABAA receptor modular-3 Chemical Structure

GABAA receptor modular-3 Chemical Structure

CAS No. : 3021554-08-2

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  • 生物活性

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生物活性

GABAA receptor modular-3 (Compound S28) is a modulator for (γ-aminobutyric acid)A receptor (GABAA receptor), with EC50 of 56 nM and 10 nM, for α1β2γ2 and α4β3δ subtype. GABAA receptor modular-3 exhibits good pharmacokinetic characteristics in rats. GABAA receptor modular-3 is slightly toxic toxicity in rats with a loss of rollover reflex (LORR) threshold dose of 23.3 μmol/kg, and exhibits potential ameliorating the postpartum depression[1].

IC50 & Target

EC50: 56 nM (GABAA receptor α1β2γ2); 10 nM (GABAA receptor α4β3δ)
分子量

514.61

Formula

C28H36F2N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GABAA receptor modular-3 相关分类

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Keywords:

GABAA receptor modular-33021554-08-2GABAA receptor modular3GABAA receptor modular 3GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorPPDpostpartum depressionSprague-Dawley ratInhibitorinhibitorinhibit

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