2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. GABAA receptor modulator-2

GABAA receptor modulator-2 (Compound 20) 是一种选择性的、具有口服活性的 α5-GABAAR 负向变构调节剂，Ki 值为 4.1 nM。GABAA receptor modulator-2 具有高代谢稳定性和良好的中枢神经系统安全性。

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GABAA receptor modulator-2 Chemical Structure

GABAA receptor modulator-2 Chemical Structure

CAS No. : 2413850-54-9

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GABAA receptor modulator-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABAAR negative allosteric modulator (NAM) with a Ki of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety[1].

IC50 & Target

Ki: 4.1 nM (hα5)[1]
体内研究
(In Vivo)

GABAA receptor modulator-2 (Compound 20) (0-10 mg/kg) produces a dose-dependent reversal of the PCP-induced cognitive deficit in the rat subPCP NOR test[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

459.49

Formula

C22H22FN3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GABAA receptor modulator-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GABAA receptor modulator-22413850-54-9GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorcentral nervous systemCNSmetabolic stabilityInhibitorinhibitorinhibit

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