2. Immunology/Inflammation
  3. Galectin
  4. Galectin-3-IN-4

Galectin-3-IN-4 (compound 5) 是一种羧酰胺类似物。Galectin-3-IN-4 是一种有效的、选择性的、口服生物可利用的人和小鼠 Galectin-3 抑制剂，对 hGal-3 和 mGal-3 的 IC50 值分别为 21 和 167 nM。 Galectin-3-IN-4 对于 hGal-1 和 hGal-9 的 IC50 值分别为 1580 和 2750 nM[1]。

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Galectin-3-IN-4 Chemical Structure

Galectin-3-IN-4 Chemical Structure

CAS No. : 2496515-38-7

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Galectin-3-IN-4 相关抗体

Top Publications Citing Use of Products

查看 Galectin 亚型特异性产品:

查看所有亚型
Galectin-1 Galectin-3 Galectin-4 Galectin-8

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Galectin-3-IN-4 (compound 5) is a carboxamide analog. Galectin-3-IN-4 is a potent, selective, and orally bioavailable inhibitor of human and mouse galectin-3, with IC50 values of 21 and 167 nM for hGal-3 and mGal-3, respectively. Galectin-3-IN-4 has IC50 values of 1580 and 2750 nM for hGal-1 and hGal-9, respectively[1].

IC50 & Target

Galectin-3

21 nM (IC50, hGal-3)

Galectin-3

167 nM (IC50, mGal-3)

Galectin-1

1580 nM (IC50, hGal-1)

体内研究
(In Vivo)

Galectin-3-IN-4 (compound 5) (2 mg/kg IV, 10 mg/kg PO; once) 具有低清除率 (CL=12 mL/min/kg) 和高分布容积 (Vss=2.1 L/kg），小鼠口服生物利用度为 52%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

565.98

Formula

C24H22ClF2N5O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Galectin-3-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Galectin-3-IN-42496515-38-7GalectinCarboxamideInhibitorinhibitorinhibit

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产品名称：
Galectin-3-IN-4
目录号：
HY-163407
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