2. Immunology/Inflammation
  3. Galectin
  4. GB1908

GB1908 是一种选择性口服半乳糖凝集素-1 (galectin-1) 抑制剂，对人类和小鼠半乳糖凝集素-1 的 Ki 值分别为 57 nM 和 72 nM。GB1908 对半乳糖凝集素-3 的选择性是其 50 倍以上。GB1908 可用于肺癌研究。

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GB1908 Chemical Structure

GB1908 Chemical Structure

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Customer Review

GB1908 相关抗体

Top Publications Citing Use of Products

查看 Galectin 亚型特异性产品:

查看所有亚型
Galectin-1 Galectin-3 Galectin-4 Galectin-8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GB1908 is a selective and orally active galectin-1 inhibitor with Ki values of 57 nM and 72 nM for human and mouse galectin-1, respectively. GB1908 displays >50-fold selectivity over galectin-3. GB1908 can be used for the study of lung cancer[1].

IC50 & Target[1]

Galectin-1

57 nM (Ki, Human galectin-1)

Galectin-1

72 nM (Ki, Mouse galectin-1)

Galectin-3

6000 nM (Ki, Human galectin-3)

Galectin-3

4200 nM (Ki, Mouse galectin-3)

体外研究
(In Vitro)

GB1908（0.1-10 μM；16 小时）可抑制 Jurkat 细胞中半乳糖凝集素-1 诱导的细胞凋亡（IC50 为 850 nM）[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GB1908 相关抗体:

Apoptosis Analysis[1]

Cell Line: Jurkat cells treatment with galectin-1
Concentration: 0.1-10 μM
Incubation Time: 16 h
Result: Inhibited galectin-1-induced apoptosis.
体内研究
(In Vivo)

GB1908（化合物 5d；30 mg/kg；口服；每天两次；持续 21 天）在同源小鼠模型中降低了原发性肺癌 LL/2 的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6N mice injected with LL/2 (LLC1) Lewis lung carcinoma cells[1]
Dosage: 30 mg/kg (PEG300/Solutol HS15/Tween 20 solution (85/15/1% v/v))
Administration: po; twice a day; for 21 days
Result: Significantly inhibited tumor growth.
分子量

505.40

Formula

C18H18Cl2N4O5S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GB1908 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GB1908GB 1908GB-1908Galectinorally activegalectin-1 inhibitorlung cancerInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-162561
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