2. Gene
  3. CDH4 - cadherin 4 Gene

CDH4 - cadherin 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钙粘素 4

种属: Homo sapiens

同用名: CAD4; RCAD; R-CAD

基因 ID: 1002 | 基因类型: protein coding

关于 CDH4

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:61,252,261-61,940,617 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 261 orthologues and 33 paralogues. Biased expression in spleen (RPKM 3.2), brain (RPKM 3.1) and 6 other tissues.

功能概要

该基因是来自钙粘蛋白超家族的经典钙粘蛋白。编码的蛋白质是一种钙依赖性细胞粘附糖蛋白，由五个细胞外钙粘蛋白重复序列、一个跨膜区域和一个高度保守的细胞质尾部组成。基于对鸡和小鼠的研究，这种钙粘蛋白被认为在大脑分割和神经元生长过程中发挥重要作用。此外，还表明其在肾脏和肌肉发育中的作用。特别感兴趣的是显示共转染细胞系中钙粘蛋白 2 和 4 的稳定顺式异二聚体的研究。以前认为以完全嗜同的方式相互作用，这是钙粘蛋白异二聚化的第一个证据。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2011 年 11 月]

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of Cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

CDH4 基因产物(3)

mRNA Protein Name
NM_001252338.2 NP_001239267.1 cadherin-4 isoform 2
NM_001252339.3 NP_001239268.1 cadherin-4 isoform 3
NM_001794.5 NP_001785.2 cadherin-4 isoform 1 preproprotein

CDH4 蛋白结构

Cadherin_pro

Cadherin_pro: Cadherin prodomain like (30 - 117)

Cadherin

Cadherin: Cadherin domain (176 - 266)

Cadherin

Cadherin: Cadherin domain (282 - 383)

Cadherin

Cadherin: Cadherin domain (398 - 498)

Cadherin

Cadherin: Cadherin domain (514 - 604)

Cadherin_C

Cadherin_C: Cadherin cytoplasmic region (758 - 912)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 916 a.a.
蛋白主名 其他名称

cadherin-4

R-cadherin

重组 CDH4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77172 R-Cadherin/CDH4 Protein, Human (HEK293, His) P55283 (H21-A734) ≥95%

关联疾病

疾病名称 别名
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Craniofacial-Deafness-Hand Syndrome

CDHS

Craniofacial Deafness Hand Syndrome

Sommer-Young-Wee-Frye Syndrome

Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss

Craniofacial-Hearing Loss-Hand Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02337 CDH4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CDH4 VGNC VGNC:60683
Rattus norvegicus CDH4 RGD RGD:621091
Canis familiaris CDH4 VGNC VGNC:49712
Mus musculus CDH4 MGD MGI:99218
Bos taurus CDH4 VGNC VGNC:27104
Macaca mulatta CDH4 VGNC VGNC:70972
Others CDH4 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z