ABCA9 - ATP binding cassette subfamily A member 9 Gene

中文名称：ATP 结合盒亚家族 A 成员 9

种属: Homo sapiens

同用名: EST640918

关于 ABCA9

功能概要

该基因是 ATP 结合盒 (ABC) 转运蛋白超家族的成员，编码的蛋白质包含两个跨膜结构域和两个核苷酸结合折叠。 ABC 蛋白可跨细胞外膜和细胞内膜转运各种分子。 ABC 基因分为七个不同的亚家族 (ABC1、MDR/TAP、MRP、ALD、OABP、GCN20 和 White) 。该基因是 ABC1 亚家族的成员，与染色体 17q24 上的其他四个 ABC1 家族成员聚集在一起。该基因的转录表达在单核细胞分化为巨噬细胞的过程中被诱导，并受到胆固醇输入的抑制。[RefSeq 提供，2008 年 7 月]

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two transmembrane domains and two nucleotide binding folds. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This gene is a member of the ABC1 subfamily and is clustered with four Other ABC1 family members on chromosome 17q24. Transcriptional expression of this gene is induced during monocyte differentiation into macrophages and is suppressed by Cholesterol import. [provided by RefSeq, Jul 2008]