KIF12 - kinesin family member 12 Gene

中文名称：驱动蛋白家族成员 12

种属: Homo sapiens

同用名: PFIC8

基因 ID: 113220 | 基因类型: protein coding

关于 KIF12

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:114,091,638-114,099,292 (from NCBI)

This gene has 8 transcripts (splice variants), 116 orthologues, 41 paralogues and is associated with 1 phenotype. Biased expression in kidney (RPKM 28.1), gall bladder (RPKM 9.6) and 9 other tissues.

功能概要

该基因编码微管相关分子马达的驱动蛋白超家族的成员，其功能与微管细胞骨架相关。这个超家族的成员在细胞内运输和细胞分裂中起着重要作用。小鼠中的一种类似蛋白质在 β 细胞抗氧化信号级联中发挥作用，充当转录因子特异性蛋白 1 (Sp1) 的支架。缺乏该基因的小鼠表现出导致低胰岛素葡萄糖不耐受的 β 细胞氧化应激。[RefSeq 提供，2016 年 7 月]

This gene encodes a member of the Kinesin superfamily of microtubule-associated molecular motors with functions related to the microtubule cytosekelton. Members of this superfamily play important roles in intracellular transport and cell division. A similar protein in mouse functions in the beta cell antioxidant signaling cascade, acting as a scaffold for the transcription factor specificity protein 1 (Sp1). Mice that lack this gene exhibit beta cell oxidative stress resulting in hypoinsulinemic glucose intolerance. [provided by RefSeq, Jul 2016]

KIF12 基因产物(10)

mRNA	Protein	Name
XM_024447406.2	XP_024303174.1	kinesin-like protein KIF12 isoform X5
NM_138424.2	NP_612433.1	kinesin-like protein KIF12 isoform 1
XR_007061239.1
XM_047422709.1	XP_047278665.1	kinesin-like protein KIF12 isoform X1
XM_005251683.6	XP_005251740.1	kinesin-like protein KIF12 isoform X3
XM_006716947.3	XP_006717010.1	kinesin-like protein KIF12 isoform X4
XM_047422710.1	XP_047278666.1	kinesin-like protein KIF12 isoform X2
XM_047422711.1	XP_047278667.1	kinesin-like protein KIF12 isoform X6
NM_001388308.1	NP_001375237.1	kinesin-like protein KIF12 isoform 2
XR_007061240.1

基因本体论

细胞组分

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular exosome	IDA IDA: 通过直接分析推断	21082674	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KIF12 蛋白结构

Kinesin

0
100
200
300
400
513 a.a.

蛋白主名

其他名称

kinesin-like protein KIF12

关联疾病

疾病名称

别名

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Cholestasis, Progressive Familial Intrahepatic, 8

PFIC8

Megabladder, Congenital

MGBL	Congenital Megabladder

Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

Autosomal Recessive Polycystic Kidney Disease	Arpkd
Polycystic Kidney Disease, Autosomal Recessive	Polycystic Kidney And Hepatic Disease 1
Pkhd1	PKD4
Polycystic Kidney Disease 4 With Or Without Hepatic Disease	Polycystic Kidney Disease, Infantile, Type I
Polycystic Kidney Disease, Infantile Type	Polycystic Kidney, Autosomal Recessive
Pkd3, Formerly	Polycystic Kidney Disease 4, With Or Without Hepatic Disease
Arpkd/Chf	Ar-Pkd
Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease	Infantile Polycystic Kidney Disease Type I
Pkd3	Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease
Polycystic Kidney Disease 3, Autosomal Dominant

Renal Cysts And Diabetes Syndrome

RCAD	Mody5
Congenital Anomalies Of The Kidney And Urinary Tract With Diabetes	Cakut With Diabetes
Maturity-Onset Diabetes Of The Young Type 5	Tubulointerstitial Kidney Disease, Autosomal Dominant, 3
Adtkd3	Atypical Familial Juvenile Hyperuricemic Nephropathy
Atypical Fjhn	Familial Hypoplastic Glomerulocystic Kidney
Maturity-Onset Diabetes Of The Young, Type 5	Hyperuricemic Nephropathy, Familial Juvenile, Atypical
Fjhn, Atypical	Glomerulocystic Kidney Disease, Hypoplastic Type
Glomerulocystic Kidney, Familial Hypoplastic	Hypoplastic Type Glomerulocystic Kidney Disease
Glomerulocystic Kidney Disease Hypoplastic Type	Renal-Diabetes Mody5 Syndrome

Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 2	PKD2
Polycystic Kidney Disease, Adult, Type Ii	Apkd2
Polycystic Kidney Disease, Type 2	Adpkd2
Adult Polycystic Kidney Disease Type 2	Autosomal Dominant Polycystic Kidney Disease 2
Pkd-2	Polycystic Kidney Disease Adult Type Ii
Polycystic Kidney Type 2 Autosomal Dominant Disease	Kidney Disease, Polycystic, Type 2

Maturity-Onset Diabetes Of The Young, Type 3

Maturity-Onset Diabetes Of The Young Type 3	MODY3
Mody, Type Iii	Mody Type 3
Mody, Type 3	Maturity-Onset Diabetes Of The Young 3
Mody-3	Diabetes Of The Young, Maturity-Onset, Type 3

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Robinow Syndrome, Autosomal Dominant 2

Autosomal Dominant Robinow Syndrome 2	DRS2
Robinow, Autosomal Dominant Syndrome, Type 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	纯度	是否罕见病
HY-RS07256	KIF12 Human Pre-designed siRNA Set A	/	否
HY-RS07257	Kif12 Mouse Pre-designed siRNA Set A	/	否
HY-RS07258	Kif12 Rat Pre-designed siRNA Set A	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	KIF12	MGD	MGI:1098232
Bos taurus	KIF12	VGNC	VGNC:30581
Felis catus	KIF12	VGNC	VGNC:97475
Macaca mulatta	KIF12	VGNC	VGNC:73877
Canis familiaris	KIF12	VGNC	VGNC:42380
Rattus norvegicus	KIF12	RGD	RGD:1308487

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KIF12 - kinesin family member 12 Gene

关于 KIF12

功能概要

KIF12 基因产物(10)

KIF12 蛋白结构

关联疾病

直系同源

热门区域

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KIF12 - kinesin family member 12 Gene

关于 KIF12

功能概要

KIF12 基因产物(10)

KIF12 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z