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  2. Cysltr1 - cysteinyl leukotriene receptor 1 Gene

Cysltr1 - cysteinyl leukotriene receptor 1 Gene

中文名称:半胱氨酰白三烯受体 1

种属: Rattus norvegicus

同用名: Cyslt1

基因 ID: 114099 | 基因类型: protein coding

关于 Cysltr1

Primary_assembly X: 71,663,821-71,690,121 reverse strand.mRatBN7.2:CM026994.1

This gene has 2 transcripts (splice variants), 177 orthologues, 14 paralogues and is associated with 25 phenotypes. Biased expression in Lung (RPKM 3.4), Heart (RPKM 23.7) and 9 other tissues.

功能概要

该基因编码的蛋白可启动白三烯受体活性。参与炎症反应;血管生成的正向调节;和血管收缩的正调节作用。预计是质膜的组成部分。用于研究肺动脉高压。肺纤维化的生物标志物。该基因的人类直系同源物与过敏性疾病有关;哮喘;和鼻炎。与人 CYSLTR1(半胱氨酰白三烯受体 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables Leukotriene Receptor activity. Involved in inflammatory response; positive regulation of angiogenesis; and positive regulation of vasoconstriction. Predicted to be integral component of plasma membrane. Used to study pulmonary hypertension. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in allergic disease; asthma; and rhinitis. Orthologous to human CYSLTR1 (cysteinyl Leukotriene Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cysltr1 基因产物(1)

mRNA Protein Name
NM_053641.2 NP_446093.1 cysteinyl leukotriene receptor 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables leukotriene receptor activity IDA
IDA: 通过直接分析推断
12418588 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
17910051 RGD
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
21105577 RGD
involved in positive regulation of glial cell proliferation IMP
IMP: 通过突变表型推断
17910051 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
16331105 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Cysltr1 蛋白结构

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (25 - 52)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (25 - 307)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (59 - 84)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (97 - 127)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (139 - 161)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (187 - 216)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (227 - 257)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (275 - 300)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
蛋白主名 其他名称

cysteinyl leukotriene receptor 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cysltr1 NCBI NCBI:10800