CYSLTR1 - cysteinyl leukotriene receptor 1 Gene

中文名称：半胱氨酰白三烯受体 1

种属: Homo sapiens

同用名: CYSLT1; CYSLTR; CYSLT1R; HMTMF81

基因 ID: 10800 | 基因类型: protein coding

关于 CYSLTR1

Cytogenetic location: Xq21.1 Genomic coordinates (GRCh38): X:78,271,468-78,327,611 (from NCBI)

This gene has 3 transcripts (splice variants), 177 orthologues and 16 paralogues. Broad expression in urinary bladder (RPKM 6.1), spleen (RPKM 5.2) and 20 other tissues.

功能概要

该基因编码 G 蛋白偶联受体 1 家族的一个成员。编码的蛋白质是半胱氨酰白三烯的受体，并通过激活磷脂酰肌醇-钙第二信使系统参与介导支气管收缩。编码受体的激活导致支气管平滑肌细胞收缩和增殖、嗜酸性粒细胞迁移以及肺粘液层损伤。该基因的上调与哮喘有关，失调也可能与癌症有关。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 8 月]

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

CYSLTR1 基因产物(4)

mRNA	Protein	Name
NM_001282186.2	NP_001269115.1	cysteinyl leukotriene receptor 1
NM_001282188.2	NP_001269117.1	cysteinyl leukotriene receptor 1
NM_001282187.2	NP_001269116.1	cysteinyl leukotriene receptor 1
NM_006639.4	NP_006630.1	cysteinyl leukotriene receptor 1

CYSLTR1 蛋白结构

7tm_1

0
100
200
300
337 a.a.

蛋白主名

其他名称

cysteinyl leukotriene receptor 1

G-protein coupled receptor HG55	LTD4 receptor
cysteinyl leukotriene D4 receptor

关联疾病

疾病名称

别名

Aspirin-Induced Respiratory Disease

Aspirin-Sensitive Asthma

Vulvar Keratoacanthoma-Like Carcinoma

Pulmonary Eosinophilia

Asthmatic Pulmonary Eosinophilia	Eosinophilic Lung Infiltrate
Weingarten'S Syndrome

Acute Asthma

Vernal Conjunctivitis

Conjunctivitis Vernal

Conjunctivitis, Vernal

Adenoid Hypertrophy

Hypertrophy Of Adenoids	Adenoidal Hypertrophy
Enlarged Adenoids	Enlargement Of Adenoids
Adenoidal Enlargement	Adenoids, Hypertrophy
Hypertrophy Of Adenoids Alone	Adenoid Growth
Hyperplasia Of Adenoids	Hypertrophy Of Pharyngeal Tonsil

Respiratory Allergy

Airway Allergy

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

Nasal Cavity Disease

Disorder Of Nasal Cavity

Respiratory Failure

Acute Respiratory Failure	Chronic Respiratory Failure
Respiratory Insufficiency	Acute-On-Chronic Respiratory Failure
Acute And Chronic Respiratory Failure	Respiratory Insufficiency/Failure
Chronic Respiratory Disease	Respiratory Disease
Pulmonary Valve Insufficiency	Chronic Disease Of Respiratory System
Respiration Disorders	Respiratory Tract Diseases
Lung Failure Nos	Pulmonary Failure
Arf - [Acute Respiratory Failure]	Acute Respiratory Insufficiency
Acute Pulmonary Insufficiency	Acute Respiration Failure
Chronic Respiration Failure

Intrinsic Asthma

Non-Atopic Asthma

Monocytic Leukemia

Monocytic Leukaemia	Schilling'S Leukaemia
Schilling'S Leukemia	M5b Acute Differentiated Monocytic Leukemia

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Angioedema

Angioneurotic Oedema	Quincke'S Edema
Angioneurotic Edema	Giant Urticaria

Chronic Asthma

Persistent Mild Asthma

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Intermittent Asthma

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced

Rhinitis

Runny Nose

Asthma, Nasal Polyps, And Aspirin Intolerance

Asthma And Nasal Polyps	Asa Triad
Asthma, Aspirin-Induced, Susceptibility To	Asthma, Aspirin-Induced
Asthma, With Nasal Polyps And Aspirin Intolerance	ANPAI
Aia	Aspirin-Intolerant Asthma
Asthma Aspirin-Induced	Nasal Polyps Asthma And Aspirin Sensitivity
Samter Triad	Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps

Nose Disease

Nose Diseases	Disorder Of The Nose
Nasal Disorder	Abnormality Of The Nose

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-13315	Montelukast sodium	Antagonist	99.84%	是
HY-13315A	Montelukast	Antagonist	99.94%	是
HY-13315B	Montelukast dicyclohexylamine	Antagonist	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-13315S1	Montelukast-d6 sodium	Antagonist	≥96.0%	否
HY-13315S	Montelukast-d6	Antagonist	/	否
HY-RS03494	CYSLTR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS03495	Cysltr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS03496	Cysltr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CYSLTR1	VGNC	VGNC:71646
Bos taurus	CYSLTR1	VGNC	VGNC:106703
Canis familiaris	CYSLTR1	VGNC	VGNC:50295
Felis catus	CYSLTR1	VGNC	VGNC:61321
Mus musculus	CYSLTR1	MGD	MGI:1926218
Rattus norvegicus	CYSLTR1	RGD	RGD:619796

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CYSLTR1 - cysteinyl leukotriene receptor 1 Gene

关于 CYSLTR1

功能概要

CYSLTR1 基因产物(4)

CYSLTR1 蛋白结构

关联疾病

直系同源

热门区域

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CYSLTR1 - cysteinyl leukotriene receptor 1 Gene

关于 CYSLTR1

功能概要

CYSLTR1 基因产物(4)

CYSLTR1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z