TNFSF11 - TNF superfamily member 11 Gene

中文名称：TNF 超家族成员 11

种属: Rattus norvegicus

同用名: ODF; OPGL; RANKL; TRANCE

关于 TNFSF11

功能概要

预测该基因编码的蛋白可启动细胞因子活性；相同的蛋白质结合活性；和肿瘤坏死因子受体超家族结合活性。参与几个过程，包括骨吸收的正调节；破骨细胞分化的正调节；和对固定压力的反应。预计位于细胞外空间和质膜。预计是膜的组成部分。粘多糖贮积症 VI 和心肌炎的生物标志物。该基因的人类直系同源物与常染色体隐性骨硬化病 2 和骨质疏松症有关。与人类 TNFSF11（TNF 超家族成员 11）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable cytokine activity; identical protein binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including positive regulation of bone resorption; positive regulation of osteoclast differentiation; and response to immobilization stress. Predicted to be located in extracellular space and plasma membrane. Predicted to be integral component of membrane. Biomarker of mucopolysaccharidosis VI and myocarditis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF Superfamily member 11). [provided by Alliance of Genome Resources, Apr 2022]