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  2. NOXO1 - NADPH oxidase organizer 1 Gene

NOXO1 - NADPH oxidase organizer 1 Gene

中文名称:NADPH 氧化酶组织者 1

种属: Homo sapiens

同用名: SNX28; P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5

基因 ID: 124056 | 基因类型: protein coding

关于 NOXO1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,978,917-1,981,469 (from NCBI)

This gene has 7 transcripts (splice variants), 283 orthologues and 3 paralogues. Broad expression in colon (RPKM 2.7), appendix (RPKM 0.9) and 14 other tissues.

功能概要

该基因编码一个 NADPH 氧化酶 (NOX) 组织者,它正向调节 NOX1 和 NOX3。该蛋白包含一个 PX 结构域和两个 SH3 结构域。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供,2012 年 6 月]

This gene encodes an NADPH Oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

NOXO1 基因产物(4)

mRNA Protein Name
NM_001267721.2 NP_001254650.1 NADPH oxidase organizer 1 isoform d
NM_144603.4 NP_653204.1 NADPH oxidase organizer 1 isoform a
NM_172167.3 NP_751907.1 NADPH oxidase organizer 1 isoform b
NM_172168.3 NP_751908.1 NADPH oxidase organizer 1 isoform c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
16636067 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16460309 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in extracellular matrix disassembly IMP
IMP: 通过突变表型推断
19755710 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NADPH oxidase complex IDA
IDA: 通过直接分析推断
16636067 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NOXO1 蛋白结构

PX

PX: PX domain (21 - 125)

SH3_1

SH3_1: SH3 domain (247 - 288)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
蛋白主名 其他名称

NADPH oxidase organizer 1

NADPH oxidase regulatory protein

NOXO1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NOXO1 Q8NFA2 NOXA1 Homo sapiens Q86UR1
Pull Down
17126813
Intra NOXO1 Q8NFA2 NOXA1 Homo sapiens Q86UR1
Anti Bait CoIP
35031518
Intra NOXO1 Q8NFA2 CYBA Homo sapiens P13498
Pull Down
16460309
Intra NOXO1 Q8NFA2 CYBA Homo sapiens P13498
Anti Bait CoIP
35031518
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lung Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Lung

Phagocyte Bactericidal Dysfunction

Phagocytic Dysfunction

Granulomatous Disease, Chronic, Autosomal Recessive, 1

Chronic Granulomatous Disease Due To Deficiency Of Ncf-1

CGD1

Ncf1 Deficiency

Soluble Oxidase Component Ii Deficiency

Soc2 Deficiency

P47-Phox Deficiency

Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type I

Deficiency Of Neutrophil Cytosol Factor 1

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 1

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type I

Cgd, Autosomal Recessive Cytochrome B-Positive, Type I

Granulomatous Disease, Chronic, Due To Ncf1 Deficiency

Neutrophil Cytosol Factor 1 Deficiency

Chronic Granulomatous Disease 1, Autosomal Recessive

Autosomal Recessive Chronic Granulomatous Disease 1

Cdg1

Deficiency Of Ncf1

Deficiency Of P47-Phox

Deficiency Of Soc2

Deficiency Of Soluble Oxidase Component Ii

Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type I

Chronic Granulomatous Disease Due To Ncf1 Deficiency

Chronic Granulomatous Disease

Cgd

Granulomatous Disease, Chronic

Autosomal Recessive Chronic Granulomatous Disease

X-Linked Chronic Granulomatous Disease

Bridges-Good Syndrome

Congenital Dysphagocytosis

Quie Syndrome

Chronic Septic Granulomatosis

Chronic Granulomatous Disorder

Granulomatous Disease Chronic

Granulomatous Disease, Chronic, X-Linked

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NOXO1 RGD RGD:1307802
Bos taurus NOXO1 VGNC VGNC:32187
Canis familiaris NOXO1 VGNC VGNC:43907
Macaca mulatta NOXO1 VGNC VGNC:75215
Felis catus NOXO1 VGNC VGNC:82349
Mus musculus NOXO1 MGD MGI:1919143