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  3. NOXA1 - NADPH oxidase activator 1 Gene

NOXA1 - NADPH oxidase activator 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NADPH 氧化酶激活因子 1

种属: Homo sapiens

同用名: p51NOX; NY-CO-31; SDCCAG31

基因 ID: 10811 | 基因类型: protein coding

关于 NOXA1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,423,393-137,434,406 (from NCBI)

This gene has 5 transcripts (splice variants), 196 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 4.2), stomach (RPKM 4.0) and 25 other tissues.

功能概要

该基因编码一种激活 NADPH 氧化酶的蛋白质，该酶催化产生活性氧的反应。编码的蛋白质包含四个 N 端四肽结构域和一个 C 端 Src 同源 3 结构域。编码的蛋白质和氧化酶调节复合物中的蛋白质之间的相互作用通过四肽结构域发生。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a protein which activates NADPH oxidases, Enzymes which catalyze a reaction generating Reactive Oxygen Species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

NOXA1 基因产物(3)

mRNA Protein Name
NM_001256067.2 NP_001242996.1 NADPH oxidase activator 1 isoform 2
NM_001256068.2 NP_001242997.1 NADPH oxidase activator 1 isoform 3
NM_006647.2 NP_006638.1 NADPH oxidase activator 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
19755710 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
16636067 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16329988 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
16636067 GOA
enables superoxide-generating NADPH oxidase activator activity IDA
IDA: 通过直接分析推断
20609497 GOA
enables superoxide-generating NADPH oxidase activator activity IMP
IMP: 通过突变表型推断
16636067 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of hydrogen peroxide metabolic process IMP
IMP: 通过突变表型推断
16636067 GOA
involved in regulation of respiratory burst IMP
IMP: 通过突变表型推断
16636067 GOA
involved in superoxide metabolic process IMP
IMP: 通过突变表型推断
20609497 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NADPH oxidase complex IDA
IDA: 通过直接分析推断
16636067 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NOXA1 蛋白结构

TPR_2

TPR_2: Tetratricopeptide repeat (38 - 66)

PB1

PB1: PB1 domain (323 - 393)

SH3_1

SH3_1: SH3 domain (405 - 456)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 483 a.a.
蛋白主名 其他名称

NADPH oxidase activator 1

NCF2-like protein

NOXA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NOXA1 Q86UR1 RIMBP3 Homo sapiens Q9UFD9
Y2H Array
25416956
Intra NOXA1 Q86UR1 NOXO1 Homo sapiens Q8NFA2-3
Pull Down
23957209
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lung Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Lung
Granulomatous Disease, Chronic, Autosomal Recessive, 1

Chronic Granulomatous Disease Due To Deficiency Of Ncf-1

CGD1

Ncf1 Deficiency

Soluble Oxidase Component Ii Deficiency

Soc2 Deficiency

P47-Phox Deficiency

Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type I

Deficiency Of Neutrophil Cytosol Factor 1

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 1

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type I

Cgd, Autosomal Recessive Cytochrome B-Positive, Type I

Granulomatous Disease, Chronic, Due To Ncf1 Deficiency

Neutrophil Cytosol Factor 1 Deficiency

Chronic Granulomatous Disease 1, Autosomal Recessive

Autosomal Recessive Chronic Granulomatous Disease 1

Cdg1

Deficiency Of Ncf1

Deficiency Of P47-Phox

Deficiency Of Soc2

Deficiency Of Soluble Oxidase Component Ii

Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type I

Chronic Granulomatous Disease Due To Ncf1 Deficiency
Bruxism

Sleep Bruxism

Sleep-Related Bruxism

Bruxism - Teeth Grinding

Grinding Teeth

Sleep Related Bruxism

Teeth Grinding

Sleep Related Teeth Grinding
Phagocyte Bactericidal Dysfunction

Phagocytic Dysfunction
Chronic Granulomatous Disease

Cgd

Granulomatous Disease, Chronic

Autosomal Recessive Chronic Granulomatous Disease

X-Linked Chronic Granulomatous Disease

Bridges-Good Syndrome

Congenital Dysphagocytosis

Quie Syndrome

Chronic Septic Granulomatosis

Chronic Granulomatous Disorder

Granulomatous Disease Chronic

Granulomatous Disease, Chronic, X-Linked
Granulomatous Disease, Chronic, X-Linked

CGDX

Chronic Granulomatous Disease, X-Linked

X-Linked Chronic Granulomatous Disease

Cgd

Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked

Cdgx

X-Linked Chronic Cytochrome B-Negative Granulomatous Disease

Chronic Granulomatous Disease Cytochrome B-Negative X-Linked

Chronic Granulomatous Disease Cytochrome B-Positive X-Linked

Granulomatous Disease, Chronic, X-Linked, Variant
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P1435 NoxA1ds Inhibitor 95.19% 否
HY-P1435A NoxA1ds TFA Inhibitor / 否
HY-RS09465 NOXA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NOXA1 VGNC VGNC:55664
Mus musculus NOXA1 MGD MGI:2449980
Rattus norvegicus NOXA1 RGD RGD:1306687
Bos taurus NOXA1 VGNC VGNC:32186
Macaca mulatta NOXA1 VGNC VGNC:75163
Felis catus NOXA1 VGNC VGNC:102956
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