Ackr3 - atypical chemokine receptor 3 Gene

中文名称：非典型趋化因子受体 3

种属: Mus musculus

同用名: Rdc1; Cxcr7; RDC-1; CXC-R7; CXCR-7; Cmkor1

关于 Ackr3

功能概要

预测该基因编码的蛋白可启动趋化因子结合活性；趋化因子受体活性；和清道夫受体活性。在细胞群增殖的负调节和 ERK1 和 ERK2 级联的正调节的上游或内部起作用。预计位于多个细胞成分中，包括细胞表面；网格蛋白涂层坑；和核内体。预计在质膜外侧活跃。以多种结构表达，包括肾上腺；中枢神经系统;泌尿生殖系统；心;和淋巴系统。与人类 ACKR3（非典型趋化因子受体 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable chemokine binding activity; Chemokine Receptor activity; and scavenger receptor activity. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in several cellular components, including cell surface; clathrin-coated pit; and endosome. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; heart; and hemolymphoid system. Orthologous to human ACKR3 (atypical Chemokine Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]