COL15A1 - collagen type XV alpha 1 chain Gene

中文名称：XV 型胶原蛋白 alpha 1 链

种属: Homo sapiens

关于 COL15A1

功能概要

该基因编码 XV 型胶原蛋白的 α 链，它是 FACIT 胶原蛋白家族的成员 (具有间断螺旋的原纤维相关胶原蛋白) 。 XV 型胶原蛋白具有广泛的组织分布，但最强的表达位于基底膜区域，因此它可能起到将基底膜粘附到下面的结缔组织基质的作用。 XV 型胶原蛋白水解产生的 C 末端片段是 restin，它是一种与内皮抑素密切相关的潜在抗血管生成蛋白。小鼠研究表明，胶原蛋白 XV 缺乏与肌肉和微血管退化有关。[RefSeq 提供，2013 年 5 月]

This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]