2. Gene
  3. SUN5 - Sad1 and UNC84 domain containing 5 Gene

SUN5 - Sad1 and UNC84 domain containing 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 Sad1 和 UNC84 域 5

种属: Homo sapiens

同用名: SPAG4L; SPGF16; TSARG4; dJ726C3.1

基因 ID: 140732 | 基因类型: protein coding

关于 SUN5

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,983,775-33,004,433 (from NCBI)

This gene has 4 transcripts (splice variants), 137 orthologues, 4 paralogues and is associated with 2 phenotypes. Restricted expression toward testis (RPKM 7.9).

功能概要

由该基因编码的蛋白质似乎在精子发生的减数分裂阶段发挥作用。编码的蛋白质定位于精子头部和身体之间的连接处，可能参与核膜重建和核迁移。该基因的突变与无头精子综合征有关。[RefSeq 提供，2017 年 5 月]

The protein encoded by this gene appears to play a role in the meiotic stage of spermatogenesis. The encoded protein localizes to the junction between the sperm head and body and may be involved in nuclear envelope reconstitution and nuclear migration. Mutations in this gene have been implicated in acephalic spermatozoa syndrome. [provided by RefSeq, May 2017]

SUN5 基因产物(1)

mRNA Protein Name
NM_080675.4 NP_542406.2 SUN domain-containing protein 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in spermatogenesis IEP
IEP: 通过表达模式推断
12621555 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear inner membrane IDA
IDA: 通过直接分析推断
27640305 GOA
located in sperm head-tail coupling apparatus IDA
IDA: 通过直接分析推断
27640305 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SUN5 蛋白结构

Sad1_UNC

Sad1_UNC: Sad1 / UNC-like C-terminal (232 - 362)

  • 0
  • 100
  • 200
  • 300
  • 379 a.a.
蛋白主名 其他名称

SUN domain-containing protein 5

epididymis secretory sperm binding protein

SUN5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SUN5 Q8TC36 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
种属内
SUN5 Q8TC36 SPAG4 Homo sapiens Q9NPE6
Y2H Prey Pooling
32296183
种属内
SUN5 Q8TC36 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spermatogenic Failure 16

SPGF16

Acephalic Spermatozoa Syndrome

Spermatozoa, Acephalic
Male Infertility Due To Acephalic Spermatozoa

Acephalic Spermatozoa Syndrome
Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Infertility
Spermatogenic Failure 14

SPGF14
Spermatogenic Failure 15

SPGF15

Spermatogenic Failure, 15
Oligoasthenoteratozoospermia

Oat

Oligoasthenoteratospermia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14032 SUN5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SUN5 RGD RGD:1306357
Canis familiaris SUN5 VGNC VGNC:46987
Bos taurus SUN5 VGNC VGNC:35476
Felis catus SUN5 VGNC VGNC:65844
Mus musculus SUN5 MGD MGI:1923657
Macaca mulatta SUN5 VGNC VGNC:78133
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