1. Gene
  2. SPAG4 - sperm associated antigen 4 Gene

SPAG4 - sperm associated antigen 4 Gene

中文名称:精子相关抗原 4

种属: Homo sapiens

同用名: SUN4; CT127

基因 ID: 6676 | 基因类型: protein coding

关于 SPAG4

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,615,829-35,621,094 (from NCBI)

This gene has 8 transcripts (splice variants), 107 orthologues and 4 paralogues. Broad expression in testis (RPKM 8.6), pancreas (RPKM 6.3) and 20 other tissues.

功能概要

哺乳动物精子鞭毛包含两个与轴丝相关的细胞骨架结构:在中段和主段围绕轴丝的外部致密纤维和在尾部主段围绕外部致密纤维的纤维鞘。这些结构的缺陷与尾部形态异常、精子活力降低和不育有关。在大鼠中,由该基因编码的蛋白质通过亮氨酸拉链基序与外部致密纤维蛋白结合,并在精子尾部发育过程中定位于 manchette 和轴丝的微管。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2015 年 12 月]

The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

SPAG4 基因产物(2)

mRNA Protein Name
NM_001317931.1 NP_001304860.1 sperm-associated antigen 4 protein isoform 2
NM_003116.3 NP_003107.1 sperm-associated antigen 4 protein isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25775403 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SPAG4 蛋白结构

Sad1_UNC

Sad1_UNC: Sad1 / UNC-like C-terminal (292 - 423)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 437 a.a.
蛋白主名 其他名称

sperm-associated antigen 4 protein

SUN domain-containing protein 4

SPAG4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SPAG4 Q9NPE6 PGA4 Homo sapiens P0DJD7
Y2H Prey Pooling
32296183
种属内
SPAG4 Q9NPE6 SEPTIN12 Homo sapiens Q8IYM1
Anti Tag CoIP
25775403
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SPAG4 VGNC VGNC:77850
Rattus norvegicus SPAG4 RGD RGD:620151
Felis catus SPAG4 VGNC VGNC:65596
Mus musculus SPAG4 MGD MGI:2444120
Canis familiaris SPAG4 VGNC VGNC:54733
Bos taurus SPAG4 VGNC VGNC:35166