1. Gene
  2. CTSW - cathepsin W Gene

CTSW - cathepsin W Gene

中文名称:组织蛋白酶 W

种属: Homo sapiens

同用名: LYPN

基因 ID: 1521 | 基因类型: protein coding

关于 CTSW

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,879,837-65,883,741 (from NCBI)

This gene has 8 transcripts (splice variants), 454 orthologues and 12 paralogues. Biased expression in bone marrow (RPKM 42.0), spleen (RPKM 24.6) and 12 other tissues.

功能概要

由该基因编码的蛋白质是肽酶 C1 家族的成员,是一种半胱氨酸蛋白酶,可能在 T 细胞细胞溶解活性的机制或调节中具有特定功能。发现编码的蛋白质与自然杀伤细胞和细胞毒性 T 细胞的内质网内膜相关。该基因的表达受白介素 2 上调。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008]

CTSW 基因产物(1)

mRNA Protein Name
NM_001335.4 NP_001326.3 cathepsin W preproprotein

CTSW 蛋白结构

Inhibitor_I29

Inhibitor_I29: Cathepsin propeptide inhibitor domain (I29) (42 - 99)

Peptidase_C1

Peptidase_C1: Papain family cysteine protease (128 - 359)

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  • 376 a.a.
蛋白主名 其他名称

cathepsin W

lymphopain

直系同源

种属 基因名 来源 基因 ID
Felis catus CTSW VGNC VGNC:61272
Mus musculus CTSW MGD MGI:1338045
Canis familiaris CTSW VGNC VGNC:39716
Bos taurus CTSW VGNC VGNC:27819
Macaca mulatta CTSW VGNC VGNC:71563
Rattus norvegicus CTSW RGD RGD:1309354
Others CTSW NCBI