Hmgb1 - high mobility group box 1 Gene

种属: Mus musculus

同用名: p30; Hmg1; HMG-1; SBP-1

基因 ID: 15289 | 基因类型: protein coding

关于 Hmgb1

功能概要

This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

Hmgb1 基因产物(2)

mRNA	Protein	Name
NM_001313894.1	NP_001300823.1	high mobility group protein B1
NM_010439.4	NP_034569.1	high mobility group protein B1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium-dependent protein kinase regulator activity	IDA IDA: 通过直接分析推断	7741753	MGI
enables cytokine activity	IDA IDA: 通过直接分析推断	7635200	MGI
enables double-stranded DNA binding	IDA IDA: 通过直接分析推断	19890330	MGI
enables double-stranded RNA binding	IDA IDA: 通过直接分析推断	19890330	MGI
enables nucleic acid binding	EXP EXP: 通过实验结果推断	15379539	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	11099378	MGI
enables protein kinase activator activity	IDA IDA: 通过直接分析推断	7741753	MGI
enables single-stranded RNA binding	IDA IDA: 通过直接分析推断	19890330	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in base-excision repair	IMP IMP: 通过突变表型推断	17803946	MGI
acts upstream of or within cellular response to interleukin-7	IDA IDA: 通过直接分析推断	29581031	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: 通过直接分析推断	28096568	MGI
involved in chromatin organization	IDA IDA: 通过直接分析推断	18650382	MGI
involved in endothelial cell chemotaxis	IDA IDA: 通过直接分析推断	16365390	MGI
involved in endothelial cell proliferation	IDA IDA: 通过直接分析推断	16365390	MGI
acts upstream of or within eye development	IMP IMP: 通过突变表型推断	10391216	MGI
acts upstream of glycogen catabolic process	IMP IMP: 通过突变表型推断	10391216	MGI
acts upstream of or within lung development	IMP IMP: 通过突变表型推断	10391216	MGI
involved in macrophage activation involved in immune response	IMP IMP: 通过突变表型推断	19890330	MGI
acts upstream of myeloid cell differentiation	IDA IDA: 通过直接分析推断	7635200	MGI
involved in myeloid dendritic cell activation	IMP IMP: 通过突变表型推断	19890330	MGI
acts upstream of myeloid progenitor cell differentiation	IDA IDA: 通过直接分析推断	7635200	MGI
involved in plasmacytoid dendritic cell activation	IMP IMP: 通过突变表型推断	19890330	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	16365390	MGI
involved in positive regulation of autophagy	IMP IMP: 通过突变表型推断	20819940	MGI
acts upstream of or within positive regulation of glycogen catabolic process	IMP IMP: 通过突变表型推断	10391216	MGI
involved in positive regulation of innate immune response	IMP IMP: 通过突变表型推断	19890330	MGI
involved in positive regulation of interferon-alpha production	IMP IMP: 通过突变表型推断	19890330	MGI
involved in positive regulation of interferon-beta production	IMP IMP: 通过突变表型推断	19890330	MGI
involved in positive regulation of interleukin-1 beta production	IMP IMP: 通过突变表型推断	19890330	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: 通过突变表型推断	19264983	MGI
involved in positive regulation of monocyte chemotactic protein-1 production	IMP IMP: 通过突变表型推断	19264983	MGI
acts upstream of or within positive regulation of myeloid cell differentiation	IDA IDA: 通过直接分析推断	7635200	MGI
acts upstream of or within positive regulation of myeloid progenitor cell differentiation	IDA IDA: 通过直接分析推断	7635200	MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	16267105	MGI
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: 通过直接分析推断	7741753	MGI
involved in positive regulation of sprouting angiogenesis	IDA IDA: 通过直接分析推断	16365390	MGI
involved in positive regulation of toll-like receptor 2 signaling pathway	IDA IDA: 通过直接分析推断	16267105	MGI
involved in positive regulation of toll-like receptor 4 signaling pathway	IDA IDA: 通过直接分析推断	16267105	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	10391216	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: 通过突变表型推断	19264983	MGI
involved in positive regulation of wound healing	IDA IDA: 通过直接分析推断	16365390	MGI
involved in regulation of T cell mediated immune response to tumor cell	IDA IDA: 通过直接分析推断	23108142	MGI
involved in regulation of nucleotide-excision repair	IMP IMP: 通过突变表型推断	18650382	MGI
involved in regulation of tolerance induction	IMP IMP: 通过突变表型推断	18631454	MGI
acts upstream of or within response to glucocorticoid	IMP IMP: 通过突变表型推断	10391216	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	10391216	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	9767109	MGI
located in early endosome	IDA IDA: 通过直接分析推断	19890330	MGI
located in extracellular space	IDA IDA: 通过直接分析推断	7635200	MGI
located in neuron projection	IDA IDA: 通过直接分析推断	12609598	MGI
located in nucleus	IDA IDA: 通过直接分析推断	9767109	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

high mobility group protein B1

amphoterin

high mobility group protein 1

重组 Hmgb1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73104	HMGB1/HMG-1 Protein, Mouse (HEK293, Fc, solution)	P63158 (M1-E215)	≥95%
HY-P73104A	HMGB1/HMG-1 Protein, Mouse (HEK293, Fc)	P63158 (M1-E215)	≥95%
HY-P700182AF	Animal-Free HMGB1/HMG-1 Protein, Mouse (His)	P63158 (M1-E215)	≥95%

目录号	产品名	作用方式	纯度	是否罕见病
HY-N0184	Glycyrrhizic acid	Inhibitor	99.84%	是
HY-B0581	Dexrazoxane		99.88%	是
HY-N0184A	Dipotassium glycyrrhizinate	Inhibitor	99.68%	是
HY-N0184R	Glycyrrhizic acid (Standard)	Inhibitor	/	否

目录号	产品名	作用方式	纯度	Phase
HY-Y1362	Ethyl pyruvate		99.87%	Phase 4

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-101872	GSK-872	Inhibitor	99.91%	否
HY-101872A	GSK-872 hydrochloride	Inhibitor	99.21%	否
HY-111815A	N4-Acetylcytidine triphosphate sodium		99.43%	否
HY-113772	Inflachromene		99.88%	否
HY-P2268A	RAGE antagonist peptide TFA	Antagonist	99.71%	否
HY-P2268	RAGE antagonist peptide	Antagonist	98.81%	否
HY-124750	NecroX-7	Inhibitor	99.69%	否
HY-148226	20-5,14-HEDGE		98.74%	否
HY-162065	N6F11	Inducer	98.37%	否
HY-N2055	Kaempferol 3-O-sophoroside		99.84%	否
HY-155751	HMGB1-IN-1	Inhibitor	99.37%	否
HY-111815	N4-Acetylcytidine triphosphate		/	否
HY-143456	Anti-inflammatory agent 18	Inhibitor	/	否
HY-143457	Anti-inflammatory agent 19	Inhibitor	/	否
HY-155759	HMGB1-IN-2	Inhibitor	/	否
HY-163409	CGK012	Inhibitor	/	否
HY-168053	HMGB1-IN-3		/	否
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	否
HY-N9587	Tricin 7-O-β-D-glucopyranoside	Inducer	/	否
HY-RS06232	HMGB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-110051	DPP4-In hydrochloride		/	否
HY-19421	Orazamide		/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Hmgb1	NCBI	NCBI:3146

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Hmgb1 - high mobility group box 1 Gene

关于 Hmgb1

功能概要

Hmgb1 基因产物(2)

重组 Hmgb1 蛋白

直系同源

热门区域

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Hmgb1 - high mobility group box 1 Gene

关于 Hmgb1

功能概要

Hmgb1 基因产物(2)

重组 Hmgb1 蛋白

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z