1. Gene
  2. Hsp90aa1 - heat shock protein 90, alpha (cytosolic), class A member 1 Gene

Hsp90aa1 - heat shock protein 90, alpha (cytosolic), class A member 1 Gene

中文名称:热休克蛋白 90 , α (胞质) ,A 类成员 1

种属: Mus musculus

同用名: hsp4; 86kDa; 89kDa; Hsp89; Hsp90; Hspca; Hsp86-1

基因 ID: 15519 | 基因类型: protein coding

关于 Hsp90aa1

Chromosome 12: 110,657,039-110,669,162 reverse strand.GRCm39:CM001005.3

This gene has 8 transcripts (splice variants), 277 orthologues, 3 paralogues and is associated with 36 phenotypes. Broad expression in placenta adult (RPKM 235.9), CNS E11.5 (RPKM 213.3) and 19 other tissues.

功能概要

实现相同的蛋白质结合活性;一氧化氮合酶调节活性;和蛋白质折叠伴侣。参与几个过程,包括轴突发生;氮化合物代谢过程的正向调控;蛋白激酶 B 信号的正调控。位于多个细胞成分中,包括生长锥;神经细胞体;和荷叶边膜。部分含蛋白质复合物。以多种结构表达,包括第 1 鳃弓;消化系统;眼睛;泌尿生殖系统;和神经系统。与人类 HSP90AA1(热休克蛋白 90 α 家族 A 类成员 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables identical protein binding activity; nitric-oxide synthase regulator activity; and protein folding chaperone. Involved in several processes, including axonogenesis; positive regulation of nitrogen compound metabolic process; and positive regulation of protein kinase B signaling. Located in several cellular components, including growth cone; neuronal cell body; and ruffle membrane. Part of protein-containing complex. Is expressed in several structures, including 1st branchial arch; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human HSP90AA1 (heat shock protein 90 alpha family class A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsp90aa1 基因产物(1)

mRNA Protein Name
NM_010480.5 NP_034610.1 heat shock protein HSP 90-alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
12885400 MGI
enables nitric-oxide synthase regulator activity IDA
IDA: 通过直接分析推断
12855682 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12855682 MGI
enables protein folding chaperone IMP
IMP: 通过突变表型推断
24286867 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to heat IMP
IMP: 通过突变表型推断
27496612 MGI
involved in positive regulation of nitric oxide biosynthetic process IDA
IDA: 通过直接分析推断
12855682 MGI
involved in protein folding IMP
IMP: 通过突变表型推断
27496612 MGI
involved in regulation of protein localization IMP
IMP: 通过突变表型推断
24286867 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axonal growth cone IDA
IDA: 通过直接分析推断
24286867 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
17908927 MGI
located in cytosol IDA
IDA: 通过直接分析推断
17923681 MGI
located in dendritic growth cone IDA
IDA: 通过直接分析推断
24286867 MGI
located in intracellular anatomical structure IDA
IDA: 通过直接分析推断
9122205 MGI
located in neuronal cell body IDA
IDA: 通过直接分析推断
24286867 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
24286867 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
27496612 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Hsp90aa1 蛋白结构

PRK14083

PRK14083: cl42520 (17 - 732)

  • 0
  • 200
  • 400
  • 600
  • 733 a.a.
蛋白主名 其他名称

heat shock protein HSP 90-alpha

HSP 86

HSP86

TSTA

heat shock 86 kDa

heat shock protein 1, alpha

heat shock protein 90kDa alpha (cytosolic), class A member 1

heat shock protein, 1

heat shock protein, 86 kDa 1

heat shock protein, 89 kDa

tumor-specific transplantation 86 kDa antigen

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hsp90aa1 NCBI NCBI:3320