2. Gene
  3. APOBEC3H - apolipoprotein B mRNA editing enzyme catalytic subunit 3H Gene

APOBEC3H - apolipoprotein B mRNA editing enzyme catalytic subunit 3H Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：载脂蛋白 B mRNA 编辑酶催化亚基 3H

种属: Homo sapiens

同用名: A3H; ARP10; ARP-10

基因 ID: 164668 | 基因类型: protein coding

关于 APOBEC3H

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,097,244-39,104,067 (from NCBI)

This gene has 7 transcripts (splice variants), 88 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 1.2), colon (RPKM 1.0) and 22 other tissues.

功能概要

该基因编码载脂蛋白 B mRNA 编辑酶催化多肽 3 蛋白家族的成员。编码的蛋白质是一种胞苷脱氨酶，通过在病毒基因组中产生致命的超突变而具有抗逆转录病毒活性。该基因的多态性和可变剪接影响其抗逆转录病毒活性，并与某些人群对人类免疫缺陷病毒 1 型感染的抵抗力增强有关。可变剪接导致多个转录变体。[RefSeq 提供，2009 年 10 月]

This gene encodes a member of the Apolipoprotein B mRNA-editing Enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 Infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

APOBEC3H 基因产物(4)

mRNA Protein Name
NM_001166002.3 NP_001159474.2 DNA dC->dU-editing enzyme APOBEC-3H isoform SV-182
NM_001166003.3 NP_001159475.2 DNA dC->dU-editing enzyme APOBEC-3H isoform SV-200
NM_001166004.3 NP_001159476.2 DNA dC->dU-editing enzyme APOBEC-3H isoform SV-154
NM_181773.5 NP_861438.3 DNA dC->dU-editing enzyme APOBEC-3H isoform SV-183
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytidine deaminase activity IDA
IDA: 通过直接分析推断
16571802 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22915799 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA cytosine deamination IDA
IDA: 通过直接分析推断
16571802 GOA
involved in clearance of foreign intracellular DNA IDA
IDA: 通过直接分析推断
20062055 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
21835787 GOA
involved in negative regulation by host of viral genome replication IMP
IMP: 通过突变表型推断
18827027 GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA
IDA: 通过直接分析推断
18779051 GOA
involved in retrotransposon silencing IDA
IDA: 通过直接分析推断
18779051 GOA
involved in retrotransposon silencing IMP
IMP: 通过突变表型推断
18827027 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
22915799 GOA
is active in cytoplasm IDA
IDA: 通过直接分析推断
29290613 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
18779051 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18779051 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

APOBEC3H 蛋白结构

APOBEC_N

APOBEC_N: APOBEC-like N-terminal domain (23 - 172)

  • 0
  • 100
  • 200 a.a.
蛋白主名 其他名称

DNA dC->dU-editing enzyme APOBEC-3H

APOBEC-related protein 10

关联疾病

疾病名称 别名
Plantar Wart

Verruca Plantaris

Verrucae On Sole Of Foot

Mosaic Plantar Warts
Human Immunodeficiency Virus Type 1

Aids

Hiv/Aids

Aids, Delayed/Rapid Progression To

Hiv-1, Susceptibility To

Hiv-1 Viremia, Susceptibility To

Human Immunodeficiency Virus Type 1, Susceptibility To

Hiv-1

Aids, Slow Progression To

Rapid Progression To Aids From Hiv1 Infection

Hiv1 Infection, Resistance To

Hiv1 Infection

Hiv-1 Viremia

Aids, Resistance To

Aids, Rapid Progression To

Hiv/Aids, Susceptibility To

Hiv-1, Resistance To

Hiv1, Resistance To

Hiv1

Hiv-1 Disease, Delayed Progression Of

Hiv-1 Disease, Rapid Progression Of

Hiv Infection, Resistance To

Hiv Type 1, Susceptibility To

Hiv Type 1

Hiv-1 Infection

Human Immunodeficiency Virus I Infection

Acquired Immunodeficiency Syndrome

Hiv-Infection/Aids
Bone Giant Cell Sarcoma

Giant Cell Sarcoma Of The Bone

Giant Cell Tumor Of Bone, Malignant
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00841 APOBEC3H Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus APOBEC3H VGNC VGNC:108124
Macaca mulatta APOBEC3H VGNC VGNC:69894
Rattus norvegicus APOBEC3H RGD RGD:1307800
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