DEFB1 - defensin beta 1 Gene

中文名称：防御素β1

种属: Homo sapiens

同用名: BD1; HBD1; DEFB-1; DEFB101

基因 ID: 1672 | 基因类型: protein coding

关于 DEFB1

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:6,870,592-6,877,936 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele and 74 orthologues. Biased expression in kidney (RPKM 464.8), salivary gland (RPKM 76.4) and 2 other tissues.

功能概要

防御素形成一个由中性粒细胞产生的杀微生物和细胞毒性肽家族。防御素家族的成员在蛋白质序列上高度相似。该基因编码防御素 β1，这是一种抗菌肽，与上皮表面对微生物定植的抵抗力有关。该基因定位在防御素家族成员防御素α1 附近，并与囊性纤维化的发病机制有关。[RefSeq 提供，2008 年 7 月]

Defensins form a family of microbicidal and cytotoxic Peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]

DEFB1 基因产物(1)

mRNA	Protein	Name
NM_005218.4	NP_005209.1	beta-defensin 1 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables CCR6 chemokine receptor binding	IDA IDA: 通过直接分析推断	25122636	GOA
enables identical protein binding	IDA IDA: 通过直接分析推断	23938203	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25122636	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antibacterial humoral response	IDA IDA: 通过直接分析推断	12860195	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: 通过直接分析推断	12860195	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP IMP: 通过突变表型推断	25122636	GOA
involved in calcium-mediated signaling	IDA IDA: 通过直接分析推断	25122636	GOA
involved in defense response to Gram-negative bacterium	IMP IMP: 通过突变表型推断	25122636	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: 通过直接分析推断	12860195	GOA
involved in defense response to Gram-positive bacterium	IMP IMP: 通过突变表型推断	25122636	GOA
acts upstream of or within defense response to bacterium	IMP IMP: 通过突变表型推断	21115716	GOA
involved in innate immune response in mucosa	IDA IDA: 通过直接分析推断	12860195	GOA
involved in positive regulation of flagellated sperm motility involved in capacitation	IMP IMP: 通过突变表型推断	25122636	GOA
involved in response to bacterium	IDA IDA: 通过直接分析推断	12054642	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	7628632	GOA
located in membrane	IDA IDA: 通过直接分析推断	23938203	GOA
located in microvesicle	IDA IDA: 通过直接分析推断	23938203	GOA
located in sperm midpiece	IDA IDA: 通过直接分析推断	25122636	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DEFB1 蛋白结构

Defensin_beta

0
68 a.a.

蛋白主名

其他名称

beta-defensin 1

BD-1

DEFB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DEFB1	P60022	ASPH	Homo sapiens	Q12797-6	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DEFB1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7133	BD-1 Protein, Human	P60022 (G22-K68)	≥95%

关联疾病

疾病名称

别名

Tonsillitis

Chronic Tonsillitis

Throat Infection - Tonsillitis

Endophthalmitis

Acne

Acne Vulgaris	Acne Varioliformis
Frontalis Acne

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Gastritis

Acute Gastric Mucosal Erosion	Erosive Gastritis
Erosive Gastropathy	Gastritis Erosive
Idiopathic Erosive/Hemorrhagic Gastritis	Inflammation Of Gastric Mucosa
Gastroduodenitis	Gastritis Nos
Noninfectious Gastroenteritis	Nonbacterial Gastroenteritis Of Infant
Acute Gastric Infection	Acute Simple Gastritis
Chronic Antral Gastritis	Chronic Fundal Gastritis
Chronic Simple Gastritis	Acute Gastroduodenitis
Acute Antral Gastritis	Acute Erosive Gastritis
Bile Reflux Gastritis	Gastritis Due To Biliary Reflux

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Aggressive Periodontitis

Juvenile Periodontitis	Periodontitis, Juvenile
Prepubertal Periodontitis

Periodontitis

Chronic Pericementitis

Chronic Periodontitis

Candidiasis

Systemic Candidiasis	Invasive Candidiasis
Disseminated Candidiasis	Systemic Candida Infections
Candidiasis, Invasive

Cyclothymic Disorder

Cyclothymia	Cycloid Personality
Cyclothymic Personality	Affective Personality Disorder
Cyclothymic Personality Disorder	Cycloid Personality Disorder

Cholesteatoma Of Middle Ear

Cholesteatoma	Epidermosis Of Ear
Epidermosis Of Middle Ear	Middle Ear Cholesteatoma
Cholesteatoma Of Middle Ear And Mastoid	Cholesteatoma Of Middle Ear And/Or Mastoid
Cholesteatoma Of The Middle Ear	Congenital Cholesteatoma
Primary Acquired Cholesteatoma	Secondary Acquired Cholesteatoma
Cholesteatoma Middle Ear	Cholesteatoma, Middle Ear
Cholesterolosis Of Middle Ear	Cholesterosis Of Ear
Cholesterosis Of Middle Ear	Cholesteatoma Nos
Epidermoid Cholesteatoma	Middle Ear Granuloma

Dacryocystitis

Nasolacrimal Sac Infection

Acute Inflammation Of Lacrimal Passage

Corneal Abscess

Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc

Bipolar I Disorder

Manic Depression Nos	Manic-Depressive Illness
Bipolar Disorder Nos

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Simpson-Golabi-Behmel Syndrome, Type 1

Simpson-Golabi-Behmel Syndrome Type 1	Simpson-Golabi-Behmel Syndrome
SGBS1	Golabi-Rosen Syndrome
Simpson Dysmorphia Syndrome	Sgbs
Bulldog Syndrome	Dgsx
Sdys	Dysplasia Gigantism Syndrome, X-Linked
X-Linked Dysplasia Gigantism Syndrome	Dgsx Golabi-Rosen Syndrome
Sara Angers Syndrome	Sgb Syndrome
Mental Retardation-Overgrowth Syndrome	Simpson Dysplasia Syndrome
Simpson Syndrome	Simpson-Golabi-Behmel Syndrome 1
Dysplasia Gigantism Syndrome X-Linked

Chromosome 17q23.1-Q23.2 Deletion Syndrome

17q23.1q23.2 Microdeletion Syndrome	17q23.1-Q23.2 Microdeletion Syndrome
Del(17)(Q23.1q23.2)	Monosomy 17q23.1q23.2
Monosomy 17q23.1-Q23.2

Shigellosis

Dysentery, Bacillary	Bacillary Dysentery
Shigella Boydii Infectious Disease	Shigella Flexneri Infectious Disease
Shigella Gastroenteritis	Shigella Sonnei Infectious Disease
Shigella Infections

Preterm Premature Rupture Of The Membranes

Preterm Premature Rupture Of Membranes	PPROM
Preterm Premature Rupture Of The Membranes, Susceptibility To	Pprom - [Preterm Premature Rupture Of Membranes]
Preterm Rupture Of Membranes

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-W074890	Palmitoylglycine	Modulator	99.74%	否
HY-RS03678	DEFB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	DEFB1	VGNC	VGNC:39876
Rattus norvegicus	DEFB1	RGD	RGD:619943
Mus musculus	DEFB1	MGD	MGI:1096878
Others	DEFB1	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DEFB1 - defensin beta 1 Gene

关于 DEFB1

功能概要

DEFB1 基因产物(1)

DEFB1 蛋白结构

DEFB1 蛋白互作信息

重组 DEFB1 蛋白

关联疾病

直系同源

热门区域

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DEFB1 - defensin beta 1 Gene

关于 DEFB1

功能概要

DEFB1 基因产物(1)

DEFB1 蛋白结构

DEFB1 蛋白互作信息

重组 DEFB1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z