ADAMTS15 - ADAM metallopeptidase with thrombospondin type 1 motif 15 Gene

中文名称：具有 1 型血小板反应蛋白基序的 ADAM 金属肽酶 15

种属: Homo sapiens

关于 ADAMTS15

功能概要

该基因编码 ADAMTS (一种具有血小板反应蛋白基序的去整合素和金属蛋白酶) 蛋白家族的成员。 ADAMTS 家族成员共享几个不同的蛋白质模块，包括前肽区域、金属蛋白酶结构域、解整合素样结构域和 1 型血小板反应蛋白 (TS) 基序。这个家族的个别成员在 C 端 TS 基序的数量上有所不同，有些成员具有独特的 C 端结构域。编码的前原蛋白经过蛋白水解处理以产生成熟的酶，该酶可能在骨骼肌发育过程中的多功能加工中发挥作用。该基因可能在结直肠癌和乳腺癌中起肿瘤抑制因子的作用。[RefSeq 提供，2016 年 5 月]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature Enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]