Mmp3 - matrix metallopeptidase 3 Gene

中文名称：基质金属肽酶 3

种属: Rattus norvegicus

关于 Mmp3

功能概要

预测该基因编码的蛋白可启动金属内肽酶活性。参与多个过程，包括细胞对细胞基质粘附的反应；细胞对 interleukin-1 的反应；和对雌二醇的反应。位于多个细胞成分中，包括细胞体；树突;和细胞外空间。部分含蛋白质复合物。几种疾病的生物标志物，包括腹主动脉瘤；退行性椎间盘疾病；胃溃疡;肾小球肾炎（多发性）；和原发性胆汁性胆管炎。该基因的人类直系同源物与多种疾病有关，包括动脉疾病（多种）；癌（多发性）；晚期肾脏疾病;骨关节炎;和 von Hippel-Lindau 病。与人 MMP3（基质金属肽酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable metalloendopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to interleukin-1; and response to estradiol. Located in several cellular components, including cell body; dendrite; and extracellular space. Part of protein-containing complex. Biomarker of several diseases, including abdominal aortic aneurysm; degenerative disc disease; gastric ulcer; glomerulonephritis (multiple); and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Orthologous to human MMP3 (matrix metallopeptidase 3). [provided by Alliance of Genome Resources, Apr 2022]