2. Gene
  3. Mmp3 - matrix metallopeptidase 3 Gene

Mmp3 - matrix metallopeptidase 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：基质金属肽酶 3

种属: Mus musculus

同用名: SL-1; SLN1; Str1; EMS-2; MMP-3; SLN-1; STR-1; Stmy1

基因 ID: 17392 | 基因类型: protein coding

关于 Mmp3

Chromosome 9: 7,445,822-7,455,975 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 501 orthologues, 23 paralogues and is associated with 11 phenotypes. Biased expression in mammary gland adult (RPKM 19.5), subcutaneous fat pad adult (RPKM 2.8) and 2 other tissues.

功能概要

该基因编码细胞外基质降解酶基质金属蛋白酶家族的一个成员，这些酶参与组织重塑、伤口修复、动脉粥样硬化进展和肿瘤侵袭。编码的蛋白质通过去除 N 端激活肽而被激活，以产生具有广泛底物（如蛋白多糖、层粘连蛋白、纤连蛋白、弹性蛋白和胶原蛋白）的锌依赖性内肽酶。该基因位于 9 号染色体上的其他基质金属蛋白酶基因簇中。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded protein is activated by the removal of an N-temrinal activation peptide to generate a zinc-dependent endopeptidase with a broad range of substrates such as proteoglycans, laminin, fibronectin, elastin, and collagens. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]

Mmp3 基因产物(1)

mRNA Protein Name
NM_010809.2 NP_034939.1 stromelysin-1 preproprotein
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
20548288 MGI
involved in cellular response to reactive oxygen species IMP
IMP: 通过突变表型推断
20969476 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
20969476 MGI
involved in protein catabolic process IMP
IMP: 通过突变表型推断
20969476 MGI
involved in proteolysis IMP
IMP: 通过突变表型推断
20969476 MGI
acts upstream of or within regulation of cell migration IMP
IMP: 通过突变表型推断
11869290 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
20969476 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
20969476 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mmp3 蛋白结构

PG_binding_1

PG_binding_1: pfam01471 (29 - 88)

Peptidase_M10

Peptidase_M10: pfam00413 (109 - 265)

HX

HX: cd00094 (291 - 478)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
蛋白主名 其他名称

stromelysin-1

matrix metalloproteinase 3

progelatinase

transin-1

相关产品

Clinical Phase
生物活性分子 (7)
目录号 产品名 作用方式
纯度 Phase
HY-12170 Prinomastat 99.27% Phase 3
HY-12170A Prinomastat hydrochloride 98.18% Phase 3
HY-12270 T-5224 Inhibitor 99.59% Phase 2
HY-15768 Ilomastat Inhibitor 98.39% Phase 2
HY-N0262 Cordycepin 99.43% Phase 2
HY-19485 XL-784 Inhibitor 98.13% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (36)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13564 Batimastat Inhibitor 98.92% 否
HY-113952 Actinonin 98.61% 否
HY-110397 KP-457 Inhibitor 99.18% 否
HY-103444 ARP-100 Inhibitor ≥99.0% 否
HY-N1463 Luteolin 7-O-glucuronide Inhibitor 99.80% 否
HY-107394 UK 356618 Inhibitor 98.91% 否
HY-N1454 Apigenin-7-glucuronide Inhibitor 99.73% 否
HY-108672 NF157 Antagonist 92.9% 否
HY-107428 PD-166793 Inhibitor 99.45% 否
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% 否
HY-114418 MMP3 inhibitor 1 Inhibitor 99.03% 否
HY-107639 UK-370106 Inhibitor ≥99.0% 否
HY-P2185A NFF-3 TFA Chemical 98.54% 否
HY-119711 NNGH Inhibitor 99.6% 否
HY-12168 Tanomastat Inhibitor 99.5% 否
HY-N1940 β-Anhydroicaritin Inhibitor 99.09% 否
HY-119423 MMP Inhibitor II Inhibitor ≥99.0% 否
HY-107617 PTIQ Inhibitor / 否
HY-110397G KP-457 (GMP) Inhibitor / 否
HY-114091A PF-00356231 Inhibitor / 否
HY-12168B (Rac)-Tanomastat Inhibitor / 否
HY-152030 Tubulin/MMP-IN-2 / 否
HY-153913 MMP-9-IN-7 Inhibitor / 否
HY-167825 Barakol / 否
HY-P2089 Dnp-PYAYWMR / 否
HY-P2166 MMP3 inhibitor 3 Inhibitor / 否
HY-P2185 NFF-3 Chemical / 否
HY-P3098 Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 / 否
HY-RS08548 MMP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08549 Mmp3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08550 Mmp3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W011085 CP-471474 Inhibitor / 否
HY-117464 CM-352 Inhibitor / 否
HY-13564A Batimastat sodium salt Inhibitor / 否
HY-137370 2-Hexynyl-5′-N-ethylcarboxamidoadenosine / 否
HY-18694 CGS 27023A Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mmp3 NCBI NCBI:4314
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