DNASE1L1 - deoxyribonuclease 1 like 1 Gene

中文名称：脱氧核糖核酸酶 1 样 1

种属: Homo sapiens

同用名: XIB; G4.8; DNL1L; DNASEX; DNAS1L1

基因 ID: 1774 | 基因类型: protein coding

关于 DNASE1L1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,401,236-154,412,101 (from NCBI)

This gene has 12 transcripts (splice variants), 228 orthologues and 3 paralogues. Ubiquitous expression in spleen (RPKM 6.9), heart (RPKM 6.8) and 25 other tissues.

功能概要

该基因编码的脱氧核糖核酸酶蛋白与 DNase I 具有高度序列相似性。编码的蛋白定位于内质网并通过 N-连接糖基化进行修饰。已经观察到编码相同蛋白质的替代转录剪接变体。[RefSeq 提供，2015 年 1 月]

This gene encodes a deoxyribonuclease protein that shows high sequence similarity to DNase I. The encoded protein is localized to the endoplasmic reticulum and modified by N-linked glycosylation. Alternate transcriptional splice variants encoding the same protein have been observed. [provided by RefSeq, Jan 2015]

DNASE1L1 基因产物(5)

mRNA	Protein	Name
NM_001009932.3	NP_001009932.1	deoxyribonuclease-1-like 1 precursor
NM_001009933.3	NP_001009933.1	deoxyribonuclease-1-like 1 precursor
NM_001009934.3	NP_001009934.1	deoxyribonuclease-1-like 1 precursor
NM_001303620.2	NP_001290549.1	deoxyribonuclease-1-like 1 precursor
NM_006730.4	NP_006721.1	deoxyribonuclease-1-like 1 precursor

DNASE1L1 蛋白结构

Exo_endo_phos

0
100
200
302 a.a.

蛋白主名

其他名称

deoxyribonuclease-1-like 1

DNase I, lysosomal-like

DNASE1L1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DNASE1L1	P49184	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
种属内	DNASE1L1	P49184	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
种属内	DNASE1L1	P49184	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
种属内	DNASE1L1	P49184	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
种属内	DNASE1L1	P49184	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
种属内	DNASE1L1	P49184	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
种属内	DNASE1L1	P49184	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
种属内	DNASE1L1	P49184	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
种属内	DNASE1L1	P49184	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
种属内	DNASE1L1	P49184	SERPINH1	Homo sapiens	P50454	Validated Y2H	32814053
种属内	DNASE1L1	P49184	SERPINH1	Homo sapiens	P50454	Y2H Array	32814053
种属内	DNASE1L1	P49184	SERPINH1	Homo sapiens	P50454	Y2H Pooling	32814053
种属内	DNASE1L1	P49184	DLST	Homo sapiens	P36957	Y2H Pooling	32814053
种属内	DNASE1L1	P49184	DLST	Homo sapiens	P36957	Validated Y2H	32814053
种属内	DNASE1L1	P49184	DLST	Homo sapiens	P36957	Y2H Array	32814053
种属内	DNASE1L1	P49184	HSPA5	Homo sapiens	P11021	Crosslink	30021884
种属内	DNASE1L1	P49184	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	33961781
种属内	DNASE1L1	P49184	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
种属内	DNASE1L1	P49184	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
种属内	DNASE1L1	P49184	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
种属内	DNASE1L1	P49184	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	DNASE1L1	P49184	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	DNASE1L1	P49184	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
种属内	DNASE1L1	P49184	CDH1	Homo sapiens	P12830	Validated Y2H	32814053
种属内	DNASE1L1	P49184	CDH1	Homo sapiens	P12830	Y2H Array	32814053
种属内	DNASE1L1	P49184	CDH1	Homo sapiens	P12830	Y2H Pooling	32814053
种属内	DNASE1L1	P49184	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
种属内	DNASE1L1	P49184	GRN	Homo sapiens	P28799	Validated Y2H	32814053
种属内	DNASE1L1	P49184	GRN	Homo sapiens	P28799	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Barth Syndrome

3-Methylglutaconic Aciduria Type 2	BTHS
Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria	Mga Type Ii
Mga2	Mgca2
Mga Type 2	3-Methylglutaconic Aciduria Type Ii
3-Methylglutaconic Aciduria, Type Ii	Mga, Type Ii
3-Methylglutaconicaciduria Type 2	3-Methylglutaconicaciduria Type Ii
Taz Defect	3 Methylglutaconic Aciduria, Type Ii
Dnajc19 Defect	Cardioskeletal Myopathy-Neutropenia Syndrome
X-Linked Cardioskeletal Myopathy And Neutropenia	3-Alpha-Methylglutaconic Aciduria Type 2
Agm2	Cardioskeletal Myopathy-Neutropenia
Invm	Left Ventricular Non-Compaction Isolated X-Linked
Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked	Agammaglobulinemia 2, Autosomal Recessive

Human Monocytic Ehrlichiosis

Ehrlichiosis Chafeensis	Hme
Human Ehrlichial Infection, Human Monocytic Type

Chronic Follicular Conjunctivitis

Ehrlichiosis

Human Ehrlichiosis	He
Hey

Glycogen Storage Disease Ii

Pompe Disease	Glycogen Storage Disease Type Ii
Acid Maltase Deficiency	Gsd Ii
Gaa Deficiency	Alpha-1,4-Glucosidase Deficiency
Glycogenosis Type Ii	GSD2
Acid Alpha-Glucosidase Deficiency	Amd
Glycogen Storage Disease, Type Ii	Pompe'S Disease
Glycogen Storage Disease Type 2	Cardiomegalia Glycogenica Diffusa
Acid Maltase Deficiency Disease	Deficiency Of Alpha-Glucosidase
Glycogenosis, Generalized, Cardiac Form	Deficiency Of Glucoamylase
Deficiency Of Maltase	Generalized Glycogenosis
Glycogenosis, Type 2	Lysosomal Alpha-1,4-Glucosidase Deficiency
Glucosidase Acid-1,4-Alpha Deficiency	Aglucosidase Alfa
Deficiency Of Lysosomal Alpha-Glucosidase	Glycogen Storage Disease Due To Acid Maltase Deficiency
Alpha-1,4-Glucosidase Acid Deficiency	Gsd Due To Acid Maltase Deficiency
Gsd Type 2	Gsd Type Ii
Glycogenosis Due To Acid Maltase Deficiency	Glycogenosis Type 2
Glycogen Storage Disease 2	Cardiomegalia Glycogenica
Glycogenosis Generalized Cardiac Form	Glycogenosis Ii
Gsd-Ii	Storage Disease, Glycogen, Type Ii
Generalized Glycogen Storage Disease Of Infants	Cardiac Form Of Generalized Glycogenosis

Human Granulocytic Anaplasmosis

Human Granulocytic Ehrlichiosis	Hge
Human Ehrlichial Infection, Human Granulocytic Type	Human Anaplasmosis Due To Anaplasma Phagocytophilum

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03895	DNASE1L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	DNASE1L1	MGD	MGI:109628
Bos taurus	DNASE1L1	VGNC	VGNC:28133
Canis familiaris	DNASE1L1	VGNC	VGNC:40024
Rattus norvegicus	DNASE1L1	RGD	RGD:1359588
Felis catus	DNASE1L1	VGNC	VGNC:61552

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DNASE1L1 - deoxyribonuclease 1 like 1 Gene

关于 DNASE1L1

功能概要

DNASE1L1 基因产物(5)

DNASE1L1 蛋白结构

DNASE1L1 蛋白互作信息

关联疾病

直系同源

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DNASE1L1 - deoxyribonuclease 1 like 1 Gene

关于 DNASE1L1

功能概要

DNASE1L1 基因产物(5)

DNASE1L1 蛋白结构

DNASE1L1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z