2. Gene
  3. Pkm - pyruvate kinase, muscle Gene

Pkm - pyruvate kinase, muscle Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：丙酮酸激酶，肌肉

种属: Mus musculus

同用名: Pk3; Pk-2; Pk-3; Pkm2

基因 ID: 18746 | 基因类型: protein coding

关于 Pkm

Chromosome 9: 59,563,651-59,586,658 forward strand.GRCm39:CM001002.3

This gene has 11 transcripts (splice variants), 312 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in duodenum adult (RPKM 494.4), mammary gland adult (RPKM 485.2) and 27 other tissues.

功能概要

该基因编码的蛋白可启动 mRNA 结合活性和丙酮酸激酶活性。参与细胞质翻译的正调控。作用于糖酵解过程的上游或内部。位于纤毛；感光器内段；和粗面内质网。以多种结构表达，包括消化系统；泌尿生殖系统；神经系统;呼吸系统;和感觉器官。与人类 PKM（丙酮酸激酶 M1/2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables mRNA binding activity and Pyruvate Kinase activity. Involved in positive regulation of cytoplasmic translation. Acts upstream of or within glycolytic process. Located in cilium; photoreceptor inner segment; and rough endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PKM (Pyruvate Kinase M1/2). [provided by Alliance of Genome Resources, Apr 2022]

Pkm 基因产物(10)

mRNA Protein Name
NM_001378869.1 NP_001365798.1 pyruvate kinase PKM isoform M2
NM_001378870.1 NP_001365799.1 pyruvate kinase PKM isoform M2
NM_011099.4 NP_035229.2 pyruvate kinase PKM isoform M2
NM_001378871.1 NP_001365800.1 pyruvate kinase PKM isoform 3
NM_001378866.1 NP_001365795.1 pyruvate kinase PKM isoform M1
NM_001378868.1 NP_001365797.1 pyruvate kinase PKM isoform M2
NM_001378872.1 NP_001365801.1 pyruvate kinase PKM isoform 4
NM_001253883.2 NP_001240812.1 pyruvate kinase PKM isoform M1
NM_001405491.1 NP_001392420.1 pyruvate kinase PKM isoform M1
NM_001378867.1 NP_001365796.1 pyruvate kinase PKM isoform M1

Pkm 蛋白结构

Pyruvate_Kinase

Pyruvate_Kinase: cd00288 (41 - 529)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 531 a.a.
蛋白主名 其他名称

pyruvate kinase PKM

pyruvate kinase 3

pyruvate kinase isozymes M1/M2

pyruvate kinase muscle isozyme

threonine-protein kinase PKM2

tyrosine-protein kinase PKM2

重组 Pkm 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72053 PKM2 Protein, Mouse (Baculovirus, His) P52480 (M1-P531) ≥95%
HY-P74629 PKM2 Protein, Mouse (sf9, His) P52480 (P2-P531) ≥95%

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P1284 ZIP Inhibitor 95.72% Phase 4
HY-P1284A ZIP TFA Inhibitor / Phase 4
Pre-clinical Phase
生物活性分子 (32)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0822 Shikonin Inhibitor 99.80% 否
HY-18657 TEPP-46 Activator 99.93% 否
HY-103617 PKM2-IN-1 Inhibitor 99.79% 否
HY-19330 DASA-58 Activator 99.73% 否
HY-126585 SAICAR 99.36% 否
HY-147368 PKM2 activator 2 Activator 99.48% 否
HY-157913 PKM2-IN-6 99.77% 否
HY-D1456 TEPC466 99.43% 否
HY-139667 PKM2-IN-3 Inhibitor 99.44% 否
HY-148324 PKM2 activator 5 Activator 96.24% 否
HY-P1399A Pep2m, myristoylated TFA Inhibitor 99.77% 否
HY-155850 CIAC001 Inhibitor 99.70% 否
HY-D1876 ZY-2 95.77% 否
HY-156375 PKM2 activator 6 / 否
HY-119874 Alkannin Inhibitor / 否
HY-126585S SAICAR-d1 / 否
HY-147397 PKM2 activator 3 Activator / 否
HY-148313 PKM2 activator 4 Activator / 否
HY-148615 NPD10084 Inhibitor / 否
HY-149275 PKM2/PDK1-IN-1 / 否
HY-155668 HMG-CoA Reductase-IN-1 Inhibitor / 否
HY-155785 MTP / 否
HY-161519 PKM2 activator 7 Activator / 否
HY-B1814 Vitamin K5 Inhibitor / 否
HY-D1877 ZY-1 98.91% 否
HY-P1399 Pep2m, myristoylated Inhibitor / 否
HY-RS10602 PKM Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10603 Pkm Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10604 Pkm Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-121275 Benserazide Inhibitor / 否
HY-155849 PKM2-IN-4 Inhibitor / 否
HY-162071 PKM2-IN-5 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pkm NCBI NCBI:5315
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