2. Apoptosis Immunology/Inflammation NF-κB Autophagy Metabolic Enzyme/Protease Stem Cell/Wnt Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Autophagy Reactive Oxygen Species Apoptosis JAK
  4. MTP

MTP 是一种 PKM2 抑制剂。MTP 通过调节 caspase-3 激活来诱导癌细胞凋亡 (apoptosis)。MTP 诱导自噬 (autophagy) 并增加 ROS 生成。MTP 还抑制JAK2 信号传导。MTP 可用于口腔鳞状细胞癌的研究。

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MTP Chemical Structure

MTP Chemical Structure

CAS No. : 2377372-62-6

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MTP 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MTP is a PKM2 inhibitor. MTP induces cancer cell apoptosis by modulating caspase-3 activation. MTP induces autophagy and increases ROS generation. MTP also inhibits JAK2 signaling. MTP can be used for research of oral squamous cell carcinoma[1].

IC50 & Target

JAK2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
LNCaP IC50
> 2 μM
Compound: 1; Tr-87
Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 31465224]
MCF7 IC50
1 μM
Compound: 1; Tr-87
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 31465224]
MDA-MB-231 IC50
0.1 μM
Compound: 1; Tr-87
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 31465224]
NCI-H157 IC50
> 2 μM
Compound: 1; Tr-87
Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 31465224]
NCI-H157 IC50
> 2 μM
Compound: 1; Tr-87
Antiproliferative activity against human NCI-H157 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human NCI-H157 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 31465224]
NCI-H1650 IC50
0.2 μM
Compound: 1; Tr-87
Antiproliferative activity against human NCI-H1650 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human NCI-H1650 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 31465224]
NCI-H1975 IC50
1 μM
Compound: 1; Tr-87
Antiproliferative activity against human NCI-H1975 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 31465224]
NCI-H460 IC50
1.5 μM
Compound: 1; Tr-87
Antiproliferative activity against human H460 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human H460 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 31465224]
PC-3 IC50
0.6 μM
Compound: 1; Tr-87
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 31465224]
PC-9 IC50
0.5 μM
Compound: 1; Tr-87
Antiproliferative activity against human PC9 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human PC9 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 31465224]
分子量

516.51

Formula

C29H23F3N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MTP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MTP2377372-62-6AutophagyReactive Oxygen SpeciesApoptosisJAKJanus kinaseanticancerOSCCoral squamous cell carcinomaHSC-3JAK2 signalingInhibitorinhibitorinhibit

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