2. Gene
  3. PKM - pyruvate kinase M1/2 Gene

PKM - pyruvate kinase M1/2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丙酮酸激酶 M1/2

种属: Homo sapiens

同用名: PK3; TCB; p58; OIP3; PKM2; CTHBP; THBP1; HEL-S-30

基因 ID: 5315 | 基因类型: protein coding

关于 PKM

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:72,199,029-72,231,591 (from NCBI)

This gene has 25 transcripts (splice variants), 294 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 155.4), esophagus (RPKM 151.3) and 24 other tissues.

功能概要

该基因编码参与糖酵解的蛋白质。编码的蛋白质是一种丙酮酸激酶，可催化磷酸基团从磷酸烯醇丙酮酸转移到 ADP，生成 ATP 和丙酮酸。这种蛋白质已被证明与甲状腺激素相互作用，并可能介导甲状腺激素诱导的细胞代谢效应。已发现该蛋白与 Opa 蛋白结合，Opa 蛋白是一种参与淋球菌粘附和侵入人体细胞的细菌外膜蛋白，表明该蛋白在细菌发病机制中的作用。已经报道了几种编码几种不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 5 月]

This gene encodes a protein involved in glycolysis. The encoded protein is a Pyruvate Kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid Hormones. This protein has been found to bind Opa protein, a Bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in Bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]

PKM 基因产物(18)

mRNA Protein Name
XM_047432666.1 XP_047288622.1 pyruvate kinase PKM isoform X8
XM_047432663.1 XP_047288619.1 pyruvate kinase PKM isoform X2
NM_001206797.3 NP_001193726.1 pyruvate kinase PKM isoform d
XM_006720570.2 XP_006720633.1 pyruvate kinase PKM isoform X3
XM_047432665.1 XP_047288621.1 pyruvate kinase PKM isoform X7
XM_047432664.1 XP_047288620.1 pyruvate kinase PKM isoform X6
NM_001206798.3 NP_001193727.1 pyruvate kinase PKM isoform e
NM_182470.4 NP_872270.1 pyruvate kinase PKM isoform b
XM_047432662.1 XP_047288618.1 pyruvate kinase PKM isoform X1
NM_001206799.2 NP_001193728.1 pyruvate kinase PKM isoform f
XM_005254443.2 XP_005254500.1 pyruvate kinase PKM isoform X4
XM_005254445.6 XP_005254502.1 pyruvate kinase PKM isoform X8
NM_182471.4 NP_872271.1 pyruvate kinase PKM isoform b
NM_001316318.2 NP_001303247.1 pyruvate kinase PKM isoform g
NM_001206796.3 NP_001193725.1 pyruvate kinase PKM isoform c
NM_002654.6 NP_002645.3 pyruvate kinase PKM isoform a
NM_001411081.1 NP_001398010.1 pyruvate kinase PKM
XM_011521670.2 XP_011519972.1 pyruvate kinase PKM isoform X5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables histone H3T11 kinase activity IDA
IDA: 通过直接分析推断
22901803 GOA
enables histone H3T11 kinase activity IDA
IDA: 通过直接分析推断
22901803 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12620389 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
22306293 GOA
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
22306293 GOA
enables pyruvate kinase activity IDA
IDA: 通过直接分析推断
20005212 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
22056988 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glycolytic process IDA
IDA: 通过直接分析推断
20847263 GOA
involved in positive regulation of sprouting angiogenesis IMP
IMP: 通过突变表型推断
27199445 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22056988 GOA
involved in programmed cell death IDA
IDA: 通过直接分析推断
17308100 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18298799 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
22901803 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17308100 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PKM 蛋白结构

PK

PK: Pyruvate kinase, barrel domain (43 - 395)

PK_C

PK_C: Pyruvate kinase, alpha/beta domain (409 - 529)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 531 a.a.
蛋白主名 其他名称

pyruvate kinase PKM

OPA-interacting protein 3

PK, muscle type

cytosolic thyroid hormone-binding protein

epididymis secretory protein Li 30

pyruvate kinase 2/3

pyruvate kinase isozymes M1/M2

pyruvate kinase muscle isozyme

pyruvate kinase, muscle

threonine-protein kinase PKM2

thyroid hormone-binding protein 1

thyroid hormone-binding protein, cytosolic

tumor M2-PK

tyrosine-protein kinase PKM2

PKM 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PKM P14618 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
种属内
PKM P14618 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
种属内
PKM P14618 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
种属内
PKM P14618 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
PKM P14618 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
PKM P14618 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
PKM P14618 DAPK1 Homo sapiens P53355
Anti Bait CoIP
21725354
种属内
PKM P14618 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属内
PKM P14618 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
PKM P14618 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
PKM P14618 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
PKM P14618 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
PKM P14618 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
PKM P14618 ARRB2 Homo sapiens P32121
Anti Tag CoIP
17620599
种属内
PKM P14618 TINF2 Homo sapiens Q9BSI4
BiFC
21044950
种属内
PKM P14618 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
种属内
PKM P14618 ARRB1 Homo sapiens P49407
Anti Tag CoIP
17620599
种属间
PKM P14618 polg_hcvco Hepatitis C virus Q9WMX2
Anti Bait CoIP
18519040
种属间
PKM P14618 polg_hcvco Hepatitis C virus Q9WMX2
IF
18519040
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PKM 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7803 PKM2 Protein, Human (420 a.a, His) P14618-1 (L61-E480) ≥95%
HY-P70599 PKM2 Protein, Human (530a.a, His) P14618-1 (S2-P531) ≥95%

PKM 抗体

目录号 产品名 应用 反应物种
HY-P80870 PKM2 Antibody WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P83644 Phospho-PKM2(Tyr105)Antibody IHC-P, IHC-F, ICC/IF, FC, ELISA Human, Rat

关联疾病

疾病名称 别名
Bilirubin Metabolic Disorder

Hyperbilirubinemia

Hereditary Hyperbilirubinemia

Hyperbilirubinemia, Hereditary

Hyperbilirubinaemia
Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Pyruvate Kinase Deficiency Of Red Cells

Pyruvate Kinase Deficiency

Pk Deficiency

Pyruvate Kinase Deficiency Of Erythrocyte

Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency

Pyruvate Kinase Deficiency Of Erythrocytes

Pkd

PKRD

Hereditary Non-Spherocytic Hemolytic Anemia Due To Pyruvate Kinase Deficiency

Hnsha

Pyruvate Kinase-Deficient Hemolytic Anemia

Red Cell Pyruvate Kinase Deficiency

Deficiency Of Pyruvate Kinase

Anemia, Hemolytic, Congenital Nonspherocytic
Glycogen Storage Disease

Glycogenosis

Glycogenoses

Gsd

Storage Disease, Glycogen

Gsd - [Glycogen Storage Disease]

Glycogen Thesaurismosis

Diffuse Glycogenosis

Generalised Glycogen Storage Disease

Generalised Glycogenosis

Generalised Glycogen Storage Disease Of Infants

Glycogen Synthase Deficiency
Neonatal Jaundice

Neonatal Hyperbilirubinemia

Neonatal Icterus

Jaundice Neonatal

Jaundice, Neonatal

Hyperbilirubinemia, Neonatal
Blood Group Incompatibility
Anterior Dislocation Of Lens
Congenital Nonspherocytic Hemolytic Anemia

Hereditary Nonspherocytic Hemolytic Anemia

Hereditary Non-Spherocytic Hemolytic Anemia

Anemia, Hemolytic, Congenital Nonspherocytic

Congenital Nonspherocytic Hemolytic Anaemia

Hereditary Nonspherocytic Hemolytic Anaemia

Hnsha
Pigmentation Disease

Pigmentation Disorders

Skin Pigmentation Disorder
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Kernicterus

Bilirubin Encephalopathy

Hyperbilirubinemic Encephalopathy

Kernicterus Spectrum Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P1284 ZIP Inhibitor 98.05% Phase 4
HY-P1284A ZIP TFA Inhibitor / Phase 4
Pre-clinical Phase
生物活性分子 (35)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0822 Shikonin Inhibitor 99.80% 否
HY-18657 TEPP-46 Activator 99.93% 否
HY-103617 PKM2-IN-1 Inhibitor 99.79% 否
HY-19330 DASA-58 Activator 99.73% 否
HY-126585 SAICAR 99.36% 否
HY-147368 PKM2 activator 2 Activator 99.48% 否
HY-D1456 TEPC466 99.43% 否
HY-N2552 Vitamin K5 hydrochloride 98.00% 否
HY-139667 PKM2-IN-3 Inhibitor 99.44% 否
HY-157913 PKM2-IN-6 99.77% 否
HY-148324 PKM2 activator 5 Activator 96.24% 否
HY-155850 CIAC001 Inhibitor 99.70% 否
HY-P1399A Pep2m, myristoylated TFA Inhibitor 99.77% 否
HY-D1876 ZY-2 95.77% 否
HY-156375 PKM2 activator 6 / 否
HY-119874 Alkannin Inhibitor / 否
HY-126585S SAICAR-d1 / 否
HY-147397 PKM2 activator 3 Activator / 否
HY-148313 PKM2 activator 4 Activator / 否
HY-148615 NPD10084 Inhibitor / 否
HY-149275 PKM2/PDK1-IN-1 / 否
HY-155216 PKM2 activator 10 / 否
HY-155668 HMG-CoA Reductase-IN-1 Inhibitor / 否
HY-155785 MTP / 否
HY-161519 PKM2 activator 7 Activator / 否
HY-167832 PT109 Inhibitor / 否
HY-B1814 Vitamin K5 / 否
HY-D1877 ZY-1 98.91% 否
HY-P1399 Pep2m, myristoylated Inhibitor / 否
HY-RS10602 PKM Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10603 Pkm Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10604 Pkm Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-121275 Benserazide Inhibitor / 否
HY-155849 PKM2-IN-4 Inhibitor / 否
HY-162071 PKM2-IN-5 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PKM VGNC VGNC:55132
Rattus norvegicus PKM RGD RGD:3337
Mus musculus PKM MGD MGI:97591
Others PKM NCBI
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