2. Metabolic Enzyme/Protease
  3. Pyruvate Kinase
  4. Alkannin

Alkannin 是一种有效且特异性的肿瘤型丙酮酸激酶-M2 (PKM2) 抑制剂。Alkannin 不抑制 PKM1 和丙酮酸激酶-L (PKL)。Alkannin 可作于抗肿瘤的研究。

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Alkannin Chemical Structure

Alkannin Chemical Structure

CAS No. : 23444-65-7

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Other Forms of Alkannin:

Alkannin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent[1].

体外研究
(In Vitro)

Alkannin is a potent and specific inhibitor to PKM2, an enzyme that dictates the last rate-limiting step of glycolysis, which is essential for cancer cells’ proliferation and survival. In the absence of D-fructose-1,6-bisphosphate (FBP), the IC50 of Alkannin is 0.3 μM. In the presence of FBP (125 μM), the IC50 of Alkannin is 0.9 μM, respectively. Alkannin effectively inhibits the cellular glycolytic flux in cancer cells dominantly expressing PKM2[1].
Alkannin (2.5-20 μM, 1 hour) inhibit the rates of cellular lactate production and glucose consumption[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Alkannin 相关抗体:

Western Blot Analysis[1]

Cell Line: MCF-7 and A549 express PKM2 but not PKM1 and PKL
Concentration: 0-20 μM
Incubation Time: 1 hour
Result: Inhibited the cellular glycolytic rate in a concentration-dependent manner.
分子量

288.30

Formula

C16H16O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Alkannin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alkannin23444-65-7Pyruvate KinaseRas-induced transcriptionRas-Erk-1/2 pathwayrefractory asthmaRas/Erk activationmicrotubulesInhibitorinhibitorinhibit

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