Vitamin K5  (Synonyms: Synkamin; Synkamin base)

Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC₅₀ values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages^[1][2][3].

IC50: 28 μM (PKM2), 191 μM PKM1, 120 μM (PKL)^[2]

Vitamin K5 (0-1600 μmoL/L) 增强 UVA 辐照对大肠杆菌，蜡样芽孢杆菌， 铜绿假单胞菌， 金黄色葡萄球菌，表皮葡萄球菌和肺炎克雷伯菌的抑菌作用^[1]。
Vitamin K5 (250-1000 μmoL/L) 产生超氧阴离子自由基和羟基自由基，在 UVA 2.9 J cm^-2 的固定剂量下^[1]。
Vitamin K5 (0-100 μM; 1 h) 剂量依赖性地抑制细胞葡萄糖消耗和乳酸生成^[2]。
Vitamin K5 剂量依赖性地抑制 colon 26 细胞的增殖^[3]。
Vitamin K5 诱导细胞凋亡，增加 colon 26 细胞 caspase-3 活性^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

173.21

C₁₁H₁₁NO

83-70-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xu F, et al. Vitamin K5 is an efficient photosensitizer for ultraviolet A light inactivation of bacteria. FEMS Microbiol Lett. 2018 Feb 1;365(4).  [Content Brief]

  [2]. Chen J, et al. Vitamin K(3) and K(5) are inhibitors of tumor pyruvate kinase M2. Cancer Lett. 2012 Mar 28;316(2):204-10.  [Content Brief]

  [3]. Ogawa M, et al. Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells. Int J Oncol. 2007 Aug;31(2):323-31.  [Content Brief]